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Journal of Environmental Pathology, Toxicology and Oncology
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ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i2.60
pages 153-162

Radioprotective Role of Selenium after Single-Dose Radioiodine (131I) Exposure to Red Blood Cells of Rats

Abhilasha Sood
Department of Biophysics, Panjab University, Chandigarh, India
Vijayta Dani Chadha
Centre for Nuclear Medicine, Institute for Emerging Ares in Science and Technology, and Department of Biophysics, Panjab University, Chandigarh, India
Devinder K. Dhawan
Department of Biophysics and Centre of Nuclear Medicine, Institute for Emerging Areas in Science and Technology, Panjab University, Chandigarh, India

ABSTRAKT

The present study elucidated the protective potential of selenium following 131I-induced alterations in rat blood. Forty rats were segregated into 4 groups. Animals in Group I served as normal controls, Group II animals were injected with a single dose of 3.7 Mbq of 131I (carrier free), Group III animals were supplemented with selenium (1 ppm), and Group IV animals were given a combined treatment of selenium and 131I. 131I treatment of rats showed significant increases in total leukocyte counts (TLCs), lymphocytes, and neutrophils (monocytes and eosinophils were not recorded). These were significantly restored upon supplementation of selenium. Lipid peroxidase (LPO), glutathione peroxidase (GSH-PX), reduced glutathione (GSH), superoxide dismutase (SOD), and δ-aminolevulinic acid dehydratase (δ-ALAD) were found to be enhanced following 131I treatment. However, the levels of catalase were found to be decreased. Selenium administration to 131I-treated rats resulted in significant restoration of these enzyme activities. Scanning electron microscope (SEM) studies also revealed various surface deformities in erythrocytes after 131I treatment, which upon supplementation with selenium were significantly restored. In conclusion, selenium may prove to be an effective radioprotector following 131I treatment.

SCHLÜSSELWÖRTER: 131I, blood, oxidative stress, selenium

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