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Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Lack of Adaptive Response of Human Lymphocytes Exposed In Vivo to Low Doses of Ionizing Radiation

Volumen 23, Ausgabe 3, 2004, 12 pages
DOI: 10.1615/JEnvPathToxOncol.v23.i3.30
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ABSTRAKT

The aim of this study was to evaluate whether or not low radiation doses can induce an adaptive response in human lymphocytes exposed in vivo. We examined chromosome aberrations, micronuclei, radiosensitivity, and apoptosis in the peripheral blood of young radiation workers (mean age 35.8 ± 9) with 14.9 ± 5.2 years of occupational exposure to ionizing radiation. Adaptive response was estimated using two parameters of radiosensitivity: micronuclei and apoptosis. Baseline and radiation-induced micronuclei (2 Gy, 60Co γ-rays) were assessed with the cytochalasin block micronucleus (CBMN) test. Cytotoxicity was analyzed by flow cytom-etry for human white blood cells identifying cells that displayed apoptosis-associated DNA condensation. In the exposed group, eight out of 34 cases were dicentric-positive. A statistically significant difference (t = 3.1, p < 0.01) was found between the dicentric-positive and dicentric-negative group in the yield of baseline micronuclei. However, the yield of radiation-induced micronuclei between these groups did not differ significantly (t = −1.57, p < 0.15). An inverse correlation between baseline micronuclei and apoptosis group was noted in the dicentric-positive group (r = −0.53, p < 0.45). Our study showed that occupational exposure to low doses of ionizing radiation failed to induce adaptation of blood lymphocytes to the challenge dose. An inverse relationship between baseline micronuclei and apoptosis in the dicentric-positive group indicates that chronic exposure to low doses of ionizing radiation depresses the ability of leukocytes to undergo apoptosis. Our study also showed that the effects of radiation-induced cytotoxicity in occupationally exposed persons could be determined by flow cytometry.

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