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Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Molecular Regulation of Cholesterol Biosynthesis: Implications in Carcinogenesis

Volumen 22, Ausgabe 2, 2003, 18 pages
DOI: 10.1615/JEnvPathToxOncol.v22.i2.10
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ABSTRAKT

Cholesterol synthesis was demonstrated to be mandatory for cellular growth and serves to supply one of the necessary building blocks for new membranes demanded by dividing cells during growth. The mevalonate pathway, which is regulated through a finely tuned mechanism, is responsible mainly for cholesterol enrichment to cells. Among the various steps, the production of mevalonate from 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) is the most critically regulated step catalyzed by HMG-CoA reductase. The ability of sterols to regulate both the transcriptional rates of the reductase gene and the degradative machinery for the reductase protein provides a multilevel system for controlling the expression of this enzyme. Much convincing evidence indicates that cells manifest a higher flux through the mevalonate pathway when proliferating than when they are in the cell cycle arrest condition; furthermore, tumors undergo deregulated cholesterogenesis mainly at the critical rate-controlling juncture (i.e., the reaction catalyzed by HMG-CoA reductase). The mevalonate component of the cholesterol biosynthesis plays a key role in controlling cell proliferation by generating prenyl intermediates, particularly farnesyl and geranyl–geranyl moieties. These isoprenoids covalently modify and thus modulate the biological activity of signal transducing proteins, such as that of the Ras superfamily. The prenylated Ras-mediated signal transduction pathway provides much of the molecular information needed to trigger cell proliferation. Therefore, depletion of mevalonate can block both the processing and the transforming activities of Ras, indicating that drugs such as lovastatin and compactin, which had previously been exploited for lowering cholesterol levels, may be useful chemotherapeutic agents for treating tumors harboring oncogenic Ras mutation. In addition, Ras prenylation, which provides much of the molecular information needed to trigger cell proliferation, represents an inviting target for the design of chemotherapeutic drugs that would interrupt such signaling events and arrest tumor cell proliferation.

REFERENZIERT VON
  1. Kino T., Kozasa T., Chrousos G. P., Statin-induced blockade of prenylation alters nucleocytoplasmic shuttling of GTP-binding proteins gamma2 and beta2 and enhances their suppressive effect on glucocorticoid receptor transcriptional activity, European Journal of Clinical Investigation, 35, 8, 2005. Crossref

  2. Grabacka Maja, Placha Wojciech, Plonka Przemyslaw M., Pajak Stanislawa, Urbanska Krystyna, Laidler Piotr, Slominski Andrzej, Inhibition of melanoma metastases by fenofibrate, Archives of Dermatological Research, 296, 2, 2004. Crossref

  3. Yano Yoshihisa, Satoh Haruna, Fukumoto Keiko, Kumadaki Itsumaro, Ichikawa Tomio, Yamada Kazuhiko, Hagiwara Kiyokazu, Yano Tomohiro, Induction of cytotoxicity in human lung adenocarcinoma cells by 6-O-carboxypropyl-α-tocotrienol, a redox-silent derivative of α-tocotrienol, International Journal of Cancer, 115, 5, 2005. Crossref

  4. Crudden Gerard, Loesel Ralf, Craven Rolf J., Overexpression of the Cytochrome P450 Activator Hpr6 (Heme-1 Domain Protein/Human Progesterone Receptor) in Tumors, Tumor Biology, 26, 3, 2005. Crossref

  5. Olano-Martin Estibaliz, Molecular Mechanisms Underlaying the Health Promoting Activity of Lycopene, in Nutrigenomics, 20055079, 2005. Crossref

  6. Elson Charles, Mo Huanbiao, Role of the Mevalonate Pathway in Tocotrienol-Mediated Tumor Suppression, in Tocotrienols, 2008. Crossref

  7. Villalba Jose M, Parrado Cristina, Santos-Gonzalez Monica, Alcain Francisco J, Therapeutic use of coenzyme Q10and coenzyme Q10-related compounds and formulations, Expert Opinion on Investigational Drugs, 19, 4, 2010. Crossref

  8. Yano Tomohiro, Virgona Nantiga, Anticancer Effects of Tocotrienols and Tocopherols Irrespective of Antioxidative Properties, in Tocotrienols, 2008. Crossref

  9. Berstein Lev M., Clinical usage of hypolipidemic and antidiabetic drugs in the prevention and treatment of cancer, Cancer Letters, 224, 2, 2005. Crossref

  10. Skrobanska R., Evangelatov A., Stefanova N., Topouzova-Hristova T., Momchilova A., Pankov R., Cell proliferation inin vivo-like three-dimensional cell culture is regulated by sequestration of ERK1/2 to lipid rafts, Cell Proliferation, 47, 4, 2014. Crossref

  11. Marttinen Maija, Pajari Anne-Maria, Päivärinta Essi, Storvik Markus, Marttinen Pekka, Nurmi Tanja, Niku Mikael, Piironen Vieno, Mutanen Marja, Plant Sterol Feeding Induces Tumor Formation and Alters Sterol Metabolism in the Intestine ofApcMinMice, Nutrition and Cancer, 66, 2, 2014. Crossref

  12. Friis Søren, Olsen Jørgen H., Statin Use and Cancer Risk: An Epidemiologic Review, Cancer Investigation, 24, 4, 2006. Crossref

  13. Jiang Dongmei, Chen Yu, Zhu Yuxiang, Fu Guosheng, Xu Shiming, Expression of key enzymes in the mevalonate pathway are altered in monocrotaline-induced pulmonary arterial hypertension in rats, Molecular Medicine Reports, 16, 6, 2017. Crossref

  14. Escrich Eduard, Moral Raquel, Solanas Montserrat, Olive oil, an essential component of the Mediterranean diet, and breast cancer, Public Health Nutrition, 14, 12A, 2011. Crossref

  15. Escrich Eduard, Solanas Montserrat, Moral Raquel, Olive Oil and Other Dietary Lipids in Breast Cancer, in Advances in Nutrition and Cancer, 159, 2014. Crossref

  16. Euba Begoña, Moleres Javier, Segura Víctor, Viadas Cristina, Morey Pau, Moranta David, Leiva José, de-Torres Juan Pablo, Bengoechea José Antonio, Garmendia Junkal, Genome Expression Profiling-Based Identification and Administration Efficacy of Host-Directed Antimicrobial Drugs against Respiratory Infection by Nontypeable Haemophilus influenzae, Antimicrobial Agents and Chemotherapy, 59, 12, 2015. Crossref

  17. Teramoto Hidemi, Castellone Maria Domenica, Malek Renae L, Letwin Noah, Frank Bryan, Gutkind J Silvio, Lee Norman H, Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12, Oncogene, 24, 3, 2005. Crossref

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