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Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Prostaglandins and the Regulation of Tumor Growth

Volumen 21, Ausgabe 2, 2002, 9 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i2.20
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ABSTRAKT

Increased expression of inducible cyclooxygenase (COX-2) is associated with a wide variety of tumors. In addition, inhibitors of COX have shown a great deal of promise in vitro and in animal models as potential antitumor therapies. COX enzymes use the substrate arachidonic acid to produce prostaglandin (PG)H2, the precursor to all the prostanoids. Therefore, the release of individual prostanoids depends on the abundance and functional coupling to individual PG synthase isoenzymes. Colony stimulating factors (CSFs) are also potential antitumor agents via their ability to augment the immune response. When COX-2 is expressed, the CSF, granulocyte macrophage (GM)-CSF, and granulocyte (G)-CSF are exquisitely sensitive to endogenous PGs. In addition, the ability of COX-2 to suppress GM-CSF release is mediated via traditional IP/EP prostanoid receptors linked to cAMP-dependent pathways. Therefore, inhibition of COX-2 in tumors may have the important side effect of enhancing the immune response. Recently, novel signaling pathways for PG derivatives have been discovered; in particular the PGD2 dehydration product 15-deoxy-D12,14-(15d)-PGJ2 was identified as a ligand for the nuclear receptor/transcription factor, peroxisome proliferator-activated receptor (PPAR)-g. PPARg is present at high levels in a number of tumors, and is also present in endothelial cells. 15d-PGJ2 as well as other nonprostanoid PPARg ligands are antitumor, and antiangiogenic, by dramatically inhibiting the growth of tumor cells and endothelial cells by either causing terminal differentiation, and/or by inducing apoptosis. We have recently found that, in addition to IP and EP ligands generated by COX-2, PPARg ligands similarly inhibit GM-CSF release. Effecting individual prostanoid pathways at the level of COX expression, profile of PG products produced or selective PG receptor activation may produce novel therapies, either dependent or independent of CSF release, to target cancers.

REFERENZIERT VON
  1. Amano Y., Ishihara S., Kushiyama Y., Yuki T., Takahashi Y., Chinuki D., Miyake T., Miyaoka Y., Rumi M. A. K., Ishimura N., Adachi K., Kinoshita Y., Barrett's oesophagus with predominant intestinal metaplasia correlates with superficial cyclo-oxygenase-2 expression, increased proliferation and reduced apoptosis: changes that are partially reversed by non-steroidal anti-inflammatory drugs usage, Alimentary Pharmacology & Therapeutics, 20, 7, 2004. Crossref

  2. Jiang Ming, Shappell Scott B., Hayward Simon W., Approaches to understanding the importance and clinical implications of peroxisome proliferator-activated receptor gamma (PPAR?) signaling in prostate cancer, Journal of Cellular Biochemistry, 91, 3, 2004. Crossref

  3. Gerner Eugene W., Meyskens Frank L., Polyamines and cancer: old molecules, new understanding, Nature Reviews Cancer, 4, 10, 2004. Crossref

  4. Nylund G., Nordgren S., Delbro D. S., Demonstration of functional receptors for noradrenaline and adenosine-5'-triphosphate, but not for prostaglandin E2, in HT-29 human colon cancer cell line, Autonomic and Autacoid Pharmacology, 23, 3, 2003. Crossref

  5. Shelby Bryan D., Nelson Anne, Morris Cindy, γ-Herpesvirus neoplasia: A growing role for COX-2, Microscopy Research and Technique, 68, 3-4, 2005. Crossref

  6. Gibson Angelia D., Belani Chandra P., Cyclooxygenase-2: A Target for Chemoprevention and Treatment of Non–Small-Cell Lung Cancer, Clinical Lung Cancer, 4, 5, 2003. Crossref

  7. Nicolaou Anna, Prostanoids, in Bioactive Lipids, 2012. Crossref

  8. Masoodi Mojgan, Nicolaou Anna, Lipidomic analysis of twenty-seven prostanoids and isoprostanes by liquid chromatography/electrospray tandem mass spectrometry, Rapid Communications in Mass Spectrometry, 20, 20, 2006. Crossref

  9. Lutz Carol S., Cornett Ashley L., Regulation of genes in the arachidonic acid metabolic pathway byRNAprocessing and RNA‐mediated mechanisms, WIREs RNA, 4, 5, 2013. Crossref

  10. Menter David G, Cyclooxygenase 2 selective inhibitors in cancer treatment and prevention, Expert Opinion on Investigational Drugs, 11, 12, 2002. Crossref

  11. Ahn Ki Young, Kim Byung Hak, Lee Yong Rok, Hwang Dong-Hyuck, Chung Eun Yong, Min Kyung Rak, Kim Youngsoo, Dual inhibitory effects of furonaphthoquinone compound on enzyme activity and lipopolysaccharide-induced expression of cyclooxygenase-2 in macrophages, Biochemical and Biophysical Research Communications, 336, 1, 2005. Crossref

  12. Pham Hung, Vang Kao, Ziboh Vincent A., Dietary γ-linolenate attenuates tumor growth in a rodent model of prostatic adenocarcinoma via suppression of elevated generation of PGE2 and 5S-HETE, Prostaglandins, Leukotrienes and Essential Fatty Acids, 74, 4, 2006. Crossref

  13. Harris Raymond C., Breyer Matthew D., Breyer Richard M., Arachidonic Acid Metabolites and the Kidney, in Brenner and Rector's The Kidney, 2011. Crossref

  14. Lugo Brian, Ford Henri R., Grishin Anatoly, Molecular signaling in necrotizing enterocolitis: regulation of intestinal COX-2 expression, Journal of Pediatric Surgery, 42, 7, 2007. Crossref

  15. Zhang Jifeng, Fu Mingui, Zhao Luning, Chen Yuqing E, 15-Deoxy-prostaglandin J2 inhibits PDGF-A and -B chain expression in human vascular endothelial cells independent of PPARγ, Biochemical and Biophysical Research Communications, 298, 1, 2002. Crossref

  16. Nylund Gunnar, Andersson Marianne, Haraldsson Börje, Delbro Dick S, Effects of norepinephrine or prostaglandin E2 on extracellular acidification rate of MCG 101, or K1735-M2 tumor cells, Life Sciences, 75, 14, 2004. Crossref

  17. Jung Je-Ryong, Kil Ki-Jung, The Effects of bilobalide Extracted from Ginkgonis Folium on Inflammation, The Korea Journal of Herbology, 30, 1, 2015. Crossref

  18. Sanchez Teresa, Moreno Juan J., GR 63799X, an EP3 receptor agonist, induced S phase arrest and 3T6 fibroblast growth inhibition, European Journal of Pharmacology, 529, 1-3, 2006. Crossref

  19. Kisslov Liz, Hadad Nurit, Rosengraten Marina, Levy Rachel, HT-29 human colon cancer cell proliferation is regulated by cytosolic phospholipase A2α dependent PGE2 via both PKA and PKB pathways, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1821, 9, 2012. Crossref

  20. Kim Ji Y., Shin Jae Y., Kim Miri R., Hann Seung-Kyung, Oh Sang H., siRNA-mediated knock-down of COX-2 in melanocytes suppresses melanogenesis, Experimental Dermatology, 21, 6, 2012. Crossref

  21. Monjazeb Arta M., High Kevin P., Koumenis Constantinos, Chilton Floyd H., Inhibitors of arachidonic acid metabolism act synergistically to signal apoptosis in neoplastic cells, Prostaglandins, Leukotrienes and Essential Fatty Acids, 73, 6, 2005. Crossref

  22. Nicolaou Anna, Estdale Sian E, Tsatmali Marina, Herrero Daniel Pascual, Thody Anthony J, Prostaglandin production by melanocytic cells and the effect of α-melanocyte stimulating hormone, FEBS Letters, 570, 1-3, 2004. Crossref

  23. Uno Goichi, Ishimura Norihisa, Tada Yasumasa, Tamagawa Yuji, Yuki Takafumi, Matsushita Takashi, Ishihara Shunji, Amano Yuji, Maruyama Riruke, Kinoshita Yoshikazu, Simplified Classification of Capillary Pattern in Barrett Esophagus Using Magnifying Endoscopy With Narrow Band Imaging, Medicine, 94, 3, 2015. Crossref

  24. Helliwell Rachel J.A, Berry Elicia B.E, O’Carroll Simon J, Mitchell Murray D, Nuclear prostaglandin receptors: role in pregnancy and parturition?, Prostaglandins, Leukotrienes and Essential Fatty Acids, 70, 2, 2004. Crossref

  25. Helliwell Rachel J.A, Adams Linda F, Mitchell Murray D, Prostaglandin synthases: recent developments and a novel hypothesis, Prostaglandins, Leukotrienes and Essential Fatty Acids, 70, 2, 2004. Crossref

  26. Jung Yoo, Jung Jae, Cho Han, Choi Myung-Sook, Sung Mi-Kyung, Yu Rina, Kang Young-Hee, Park Jung, Berteroin Present in Cruciferous Vegetables Exerts Potent Anti-Inflammatory Properties in Murine Macrophages and Mouse Skin, International Journal of Molecular Sciences, 15, 11, 2014. Crossref

  27. Jeong Da-Hyun, Kim Koth-Bong-Woo-Ri, Kim Min-Ji, Kang Bo-Kyeong, Ahn Dong-Hyun, Skipjack tuna ( Katsuwonus pelamis ) eyeball oil exerts an anti-inflammatory effect by inhibiting NF-κB and MAPK activation in LPS-induced RAW 264.7 cells and croton oil-treated mice, International Immunopharmacology, 40, 2016. Crossref

  28. Larsson Susanna C, Kumlin Maria, Ingelman-Sundberg Magnus, Wolk Alicja, Dietary long-chain n−3 fatty acids for the prevention of cancer: a review of potential mechanisms, The American Journal of Clinical Nutrition, 79, 6, 2004. Crossref

  29. Vidal Sergio, Kovacs Kalman, Bell David, Horvath Eva, Scheithauer Bernd W., Lloyd Ricardo V., Cyclooxygenase-2 expression in human pituitary tumors, Cancer, 97, 11, 2003. Crossref

  30. Harks E. G. A., Peters P. H. J., van Dongen J. L. J., van Zoelen E. J. J., Theuvenet A. P. R., Autocrine production of prostaglandin F2αenhances phenotypic transformation of normal rat kidney fibroblasts, American Journal of Physiology-Cell Physiology, 289, 1, 2005. Crossref

  31. Nicolaou Anna, Masoodi Mojgan, Mir Adnan, Lipidomic Analysis of Prostanoids by Liquid Chromatography–Electrospray Tandem Mass Spectrometry, in Lipidomics, 579, 2009. Crossref

  32. Yurkovetsky Zoya R., Tourkova Irina L., Balkir Levent, Perez Lori, Shurin Galina V., Chatta Gurkamal S., Shurin Michael R., Malfunction of the Dendritic Cell System in Cancer, in Cancer Immunotherapy at the Crossroads, 2004. Crossref

  33. Seo Kyoung, Choi So , Jin Yeonsun , Son Heebin , Kang Young , Jung Seung , Kim Yong‑In , Eum Sangmi , Bach Tran , Yoo Hee , Whang Wan , Jung Sun‑Young , Kang Wonku , Ko Hyun , Lee Sung , Anti‑inflammatory role of Prunus persica L. Batsch methanol extract on lipopolysaccharide‑stimulated glial cells, Molecular Medicine Reports, 2020. Crossref

  34. Harwood John, Lloyd-Evans Emyr, Calder Philip C., Eicosanoids, Essays in Biochemistry, 64, 3, 2020. Crossref

  35. Kang Yun Sil, Chung You Chul, Lee Jung No, Kim Bong Seok, Hyun Chang-Gu, Anti-Inflammatory Effects of 6,7-Dihydroxy-4-Methylcoumarin on LPS-Stimulated Macrophage Phosphorylation in MAPK Signaling Pathways, Natural Product Communications, 16, 5, 2021. Crossref

  36. Hall-Pogar Tyra, Liang Songchun, Hague Lisa K., Lutz Carol S., Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3′-UTR , RNA, 13, 7, 2007. Crossref

  37. Hammamieh Rasha, Sumaida Dena, Zhang XiaoYan, Das Rina, Jett Marti, Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism, BMC Cancer, 7, 1, 2007. Crossref

  38. Jang Tae-Won, Park Jae-Ho, Anti-Inflammatory Effects of Abeliophyllum distichum Nakai (Cultivar Okhwang 1) Callus through Inhibition of PI3K/Akt, NF-κB, and MAPK Signaling Pathways in Lipopolysaccharide-Induced Macrophages, Processes, 9, 6, 2021. Crossref

  39. Kim Se Jin, Leem Hyun Hee, Nam Won Hee, Son Su Mi, Choi Hye Min, Kim Myung Jin, Kim Jung Ok, Lee Hwa Dong, Effect of Anti-inflammation on Oryeong-san Formulation for Mix Extract Tablet, Journal of Physiology & Pathology in Korean Medicine, 34, 6, 2020. Crossref

  40. Beam S. L., Rassnick K. M., Moore A. S., McDonough S. P., An Immunohistochemical Study of Cyclooxygenase-2 Expression in Various Feline Neoplasms, Veterinary Pathology, 40, 5, 2003. Crossref

  41. Konson Alexander, Ben-Kasus Tsipi, Mahajna Jamal A, Danon Abraham, Rimon Gilad, Agbaria Riad, Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells, Cancer Gene Therapy, 11, 12, 2004. Crossref

  42. Jeong Da-Hyun, Kim Koth-Bong-Woo-Ri, Kim Min-Ji, Kang Bo-Kyeong, Ahn Dong-Hyun, Anti-inflammatory activity of methanol extract and n-hexane fraction mojabanchromanol b from Myagropsis myagroides, Life Sciences, 114, 1, 2014. Crossref

  43. Gupta Sanjay, Adhami Vaqar M., Subbarayan Murugesan, MacLennan Gregory T., Lewin Jonathan S., Hafeli Urs O., Fu Pingfu, Mukhtar Hasan, Suppression of Prostate Carcinogenesis by Dietary Supplementation of Celecoxib in Transgenic Adenocarcinoma of the Mouse Prostate Model, Cancer Research, 64, 9, 2004. Crossref

  44. Kim Ye Jin, Son Dae-Yeul, Antioxidant activity and suppression of pro-inflammatory mediator of Corni fructus extracts in activated RAW 264.7 macrophage , Korean Journal of Food Preservation, 23, 6, 2016. Crossref

  45. Hong Shin Hyub, Lee Eun-Ho, Park Hye-Jin, Kim Jung In, Jung Hee-Young, Kang In-Kyu, Kim Byung-Oh, Park Heui-Dong, Cho Young-Je, Anti-inflammatory effect of Pyrrosia lingua extract on Raw 264.7 macrophages, Korean Journal of Food Preservation, 28, 6, 2021. Crossref

  46. Jameel Farheen, Agarwal Priyanka, Arshad Mohd., Serajuddin Mohd., Omega-3 polyunsaturated fatty acids of fish and their role in cancerous cell lines: A review of in-vitro studies, Fisheries & Aquatic Life, 27, 1, 2019. Crossref

  47. Kim Kang Sub, Choi Yea Jung, Jang Dae Sik, Lee Sullim, 2-O-β-d-Glucopyranosyl-4,6-dihydroxybenzaldehyde Isolated from Morus alba (Mulberry) Fruits Suppresses Damage by Regulating Oxidative and Inflammatory Responses in TNF-α-Induced Human Dermal Fibroblasts, International Journal of Molecular Sciences, 23, 23, 2022. Crossref

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