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Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Restorative Effect of Fucoxanthin in an Ovalbumin-Induced Allergic Rhinitis Animal Model through NF-κB p65 and STAT3 Signaling

Volumen 38, Ausgabe 4, 2019, pp. 365-375
DOI: 10.1615/JEnvironPatholToxicolOncol.2019030997
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ABSTRAKT

Allergic rhinitis is a sensitivity to allergens that causes swelling or puffiness of the nasal airways. The occurrence of allergic rhinitis is mounting worldwide. We examined whether fucoxanthin restrains the development of allergic rhinitis provoked by ovalbumin (OVA). In this study, allergic rhinitis in male BALB/c mice was induced with OVA. The object was to evaluate the effect of fucoxanthin on consequently allergic mice. Allergic responses like rubbing and sneezing were scored to reveal the effect of fucoxanthin in the induced and treated groups. Mean histological scores demonstrated variation in and between OVA-induced and fucoxanthin-treated groups in terms of ciliary loss, eosinophil infiltration, and the like. Lipid profiling (malondialdehyde) confirmed the restraining effect of fucoxanthin on allergic rhinitis. The present study showed that cytokine production, the induction of cell survival molecule NF-κB p65, and subsequent prevention of IκBα phosphorylation are controlled by fucoxanthin, and that interleukins (IL-5, IL-6, and IL-12) support STAT-3 binding to key elements that control IL-17A expression. Additionally, the study showed that interleukin-induced NF-κB and IκBα directly regulate interleukins in collaboration with STAT-3 and related cytokines. Levels of IgE and histamine are the most frequent medications used to treat allergic rhinitis. Considering our findings, we concluded that fucoxanthin represses the development of allergic rhinitis induced by OVA and thus might be a positive drug for its management.

REFERENZEN
  1. Berger WE. Allergic rhinitis in children: diagnosis and management strategies. Pediatr Drugs. 2004;6(4):233-50.

  2. Nathan RA. The burden of allergic rhinitis. Allergy Asthma Proc. 2007;28(1):3-9.

  3. Jin Y-T, Chen S, Zhu Z-Y, Wu L-T, Xuan L-H. Tlr-NF-KB signaling pathway-based investigation on the influence of acupoint application of raw and fried white mustard seed plasters on nasal mucosa in rats with allergic rhinitis. Acta Medica Mediterranea. 2018;34:1461.

  4. Wee JH, Zhang YL, Rhee CS, Kim DY. Inhibition of allergic response by intranasal selective NF-KB decoy oligodeoxynucleotides in a murine model of allergic rhinitis. Allergy Asthma Immunol Res. 2017;9(1): 61-9.

  5. Chauhan PS, Singh R. Ovalbumin-induced allergic inflammation leads to structural alterations in mouse model and protective effects of intranasal curcumin: a comparative study. Allergologia Immunopathologia. 2016;44(3):246-56.

  6. Pearson IC, Holden CA. Atopic dermatitis-a simple entity? Clin Exper Dermatol. 2002;27(1):88-9.

  7. Vliagoftis H, Befus AD. Mast cells, basophils and mucosal immunity. In: Mucosal immunology. Academic Press; 2015. p. 859-82.

  8. Webster KM, Sun M, Crack P, O'Brien TJ, Shultz SR, Semple BD. Inflammation in epileptogenesis after traumatic brain injury. J Neuroinflamm. 2017;14(1):10.

  9. Lin YH, Chen HY, Chiu JC, Chen KJ, Ho HY, Yang SH. Immunomodulation effects of Schizonepeta tenuifolia Briq. on the IgE-induced allergic model of RBL-2H3 cells. Evidence-Based Comp Alt Med. 2018;2018.

  10. Karo-Atar D, Bitton A, Benhar I, Munitz A. Therapeutic targeting of the interleukin-4/interleukin-13 signaling pathway: in allergy and beyond. BioDrugs. 2018;32(3):201-20.

  11. Zhang Y, Hou XR, Li LH, Yang M, Liang FH. Effect of acupoint injection on eosinophil counts, protein and mRNA expressions of eotaxin in nasal mucosa of allergic rhinitis rats. Acupuncture Res. 2017;42(2):141-4 (in Chinese).

  12. Park M, Hong J. Roles of NF-KB in cancer and inflammatory diseases and their therapeutic approaches. Cells. 2016;5(2):15.

  13. Harmer D, Falank C, Reagan MR. Interleukin-6 interweaves the bone marrow microenvironment, bone loss, and multiple myeloma. Front Endocrinol. 2018;9:788.

  14. Karl DM, Church MJ. Ecosystem structure and dynamics in the North Pacific subtropical gyre: new views of an old ocean. Ecosystems. 2017;20(3):433-57.

  15. Xia S, Wang K, Wan L, Li A, Hu Q, Zhang C. Production, characterization, and antioxidant activity of fucoxanthin from the marine diatom Odontella aurita. Mar Drugs 2013;11:2667-81.

  16. Mulders KJ, Lamers PP, Martens DE, Wijffels RH. Phototrophic pigment production with microalgae: biological constraints and opportunities. J Phycol. 2014;50(2): 229-42.

  17. Loredo AL, Benavides J, Palomares MR. Growth kinetics and fucoxanthin production of Phaeodactylum tricornutum and Isochrysis galbana cultures at different light and agitation conditions. J Appl Phycol. 2016;28:849-60.

  18. Mikami K, Hosokawa M. Biosynthetic pathway and health benefits of fucoxanthin, an algae-specific xanthophyll in brown seaweeds. Int J Mol Sci. 2013;14:13763-81.

  19. Peng J, Yuan JP, Wu CF, Wang JH. Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health. Mar Drugs. 2011;9:1806-28.

  20. Rengarajan T, Rajendran P, Nandakumar N, Balasubramanian M, Nishigaki I. Cancer preventive efficacy of marine carotenoid fucoxanthin: cell cycle arrest and apoptosis. Nutrients. 2013;5(12):4978-89.

  21. D'Orazio N, Gemello E, Gammone MA, De Girolamo M, Ficoneri C, Riccioni G. Fucoxanthin: a treasure from the sea. Mar Drugs. 2012;10:604-16.

  22. Iwasaki M, Saito K, Takemura M, Sekikawa K, Fujii H, Yamada Y, Wada H, Mizuta K, Seishima M, Ito Y. TNF-a contributes to the development of allergic rhinitis in mice. J Allergy Clin Immunol. 2003 Jul 1;112(1): 134-40.

  23. Xian Z, Jin G, Li H, Jiang J, Wang C, Zhu L, Jin Z, Li L, Piao H, Zheng M, Yan G. Imperatorin suppresses anaphylactic reaction and IgE-mediated allergic responses by inhibiting multiple steps of FceRI signaling in mast cells: IMP alleviates allergic responses in PCA. BioMed Res Int. 2019;2019.

  24. Green CL, Wagner AD, Glogowski J, Skipper LP, Wishnok SJ, Tannebaum RS. Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Infection Immunity. 1994;62(4):1171-5.

  25. Xu YY, Liu X, Dai LB, Zhou SH. Effect of Tong Qiao drops on the expression of eotaxin, IL-13 in the nasal mucosa of rats with allergic rhinitis. J Chin Med Assoc. 2012;75(10):524-9. doi: 10.1016/jjcma.2012.07.003.

  26. Tirkey N, Kaur G, Vij G, Chopra K. Curcumin, a diferuloyl-methane,attenuatescyclosporine-inducedrenaldysfunction and oxidative stress in rat kidneys. BMC Pharmacol. 2005; 15(5):15.

  27. Bourdin A, Gras D, Vachier I, Chanez P. Upper airway x1: allergic rhinitis and asthma: united disease through epithelial cells. Thorax. 2009;64:999-1004.

  28. Singh K, Agrawal NK, Gupta SK, Sinha P, Singh K. In-creased expression of TLR9 associated with pro-inflammatory S100A8 and IL-8 in diabetic wounds could lead to unresolved inflammation in type 2 diabetes mellitus (T2DM) cases with impaired wound healing. J Diabetes Comp. 2016;30(1):99-108.

  29. Kaur V, Kumar M, Kumar A, Kaur K, Dhillon VS, Kaur S. Pharmacotherapeutic potential of phytochemicals: implications in cancer chemoprevention and future perspectives. Biomed Pharmacother. 2018;97:564-86.

  30. Jutel M, Akdis M, Akdis CA. Histamine, histamine receptors and their role in immune pathology. Clin Exp Allergy. 2009;39:1786-800.

  31. Matsuda H, Tewtrakul S, Morikawa T, Yoshikawa M. Anti-allergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-a and IL-4 in RBL-2H3 cells. Bioorgan Med Chem. 2004;12:4871-6.

  32. Del Prete G, Maggi E, Parronchi P, Chretien I, Tiri A, Macchia D, Ricci M, Banchereau J, De Vries JE, Romagnani S. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol. 1988;140(12):4193-8.

  33. Ohmori H, Kanda T, Takai T, Hikida M. Induction of antigen-specific IgE response in murine lymphocytes by IL-10. Immunol Lett. 1995;47:127-32.

  34. Lambert AL, Selgrade MK, Winsett DW, Gilm- our MI. TNF-alpha enhanced allergic sensitization to house dust mite in brown Norway rats. Exp Lung Res. 2001;27:617-35.

  35. Hohki G, Terada N, Hamano N, Kitaura M, Nakajima T, Yoshie O, Ikeda T, Kimura S, Konno A. The effects of eotaxin on the surface adhesion molecules of endo-thelial cells and on eosinophil adhesion to microvascular endothelial cells. Biochem Biophys Res Commun. 1997;241(1):136-41.

  36. Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med. 1996;183:195-201.

  37. Kanehiro A, Lahn M, Makela MJ, Dakhama A, Fujita M, Joetham A, Mason RJ, Born W, Gelfand EW. Tumor necrosis factor-a negatively regulates airway hyperrespon-siveness through yS T cells. Am J Respiratory Crit Care Med. 2001;164(12):2229-38.

  38. Hamid Q, Tulic M. Immunobiology of asthma. Annu Rev Physiol. 2009;71:489-507.

  39. Boyce JA, Austen KF. No audible wheezing: nuggets and conundrums from mouse asthma models. J Exper Med. 2005;201(12):1869-73.

  40. Roever AC, Heine G, Zuberbier T, Worm M. Allergen-mediated modulation of CD23 expression is interferon-y and interleukin-10 dependent in allergic and non-allergic individuals. Clin Exper Allergy. 2003;33(11):1568-75.

  41. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol. 1989;7(1):145-73.

  42. Bui TT, Piao CH, Song CH, Shin HS, Chai OH. Bupleurum chinense extract ameliorates an OVA-induced murine allergic asthma through the reduction of the Th2 and Th17 cytokines production by inactivation of NFKB pathway. Biomed Pharmacother. 2017;91:1085-95.

  43. Lee WS, Shin JS, Jang DS, Lee KT. Cnidilide, an alkylph-thalide isolated from the roots of Cnidium officinale, suppresses LPS-induced NO, PGE2, IL-1P, IL-6 and TNF-a production by AP-1 and NF-KB inactivation in RAW 264.7 macrophages. Int Immunopharmacol. 2016;40:146-55.

  44. Yamanaka K, Fujisawa T, Kusagaya H, Mori K, Niwa M, Furuhashi K, Kono M, Hamada E, Suda T, Maekawa M. IL-13 regulates IL-17C expression by suppressing NF-KB-mediated transcriptional activation in airway epithelial cells. Biochem Biophys Res Commun. 2018;495(1):1534-40.

  45. Stritesky GL, Muthukrishnan R, Sehra S, Goswami R, Pham D, Travers J, Nguyen ET, Levy DE, Kaplan MH. The transcription factor STAT3 is required for T helper 2 cell development. Immunity. 2011;34(1):39-49.

  46. Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009;9(11):798.

  47. Backert SB, Koralov S, Wirtz V, Kitowski U, Billmeier E, Martini K, Hofmann K, Hildner N, Wittkopf K, Brecht M, Waldner K, Rajewsky MF, Neurath C, Becker C. Neufert C. STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis. J Immunol. 2014;193(7):3779-91.

  48. Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS. T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORa and RORy. Immunity. 2008;28(1):29-39.

  49. Bui TT, Piao CH, Hyeon E, Fan Y, Nguyen TV, Jung SY, Choi DW, Lee S-Y, Shin HS, Song CH, Chai OH. The protective role of Piper nigrum fruit extract in an ovalbumin-induced allergic rhinitis by targeting of NF-KB p65 and STAT3 signalings. Biomed Pharmacother. 2019;109:1915-23.

  50. Tadokoro T, Wang Y, Barak LS, Bai Y, Randell SH, Hogan BL. IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells. Proc Natl Acad Sci USA. 2014;111(35):E3641-E9.

  51. Maher K, Zavrsnik J, Jeric-Kokelj B, Vasiljeva O, Turk B, Kopitar-Jerala N. Decreased IL-10 expression in stefin B-deficient macrophages is regulated by the MAP kinase and STAT-3 signaling pathways. FEBS Lett. 2014;588(5):720-6.

  52. Bozdemir K, Sahin E, Altintoprak Nuray N, Betul M, Acar M, Cingi C. Is resveratrol therapeutic when used to treat allergic rhinitis in rats? Clin Invest Med. 2016;39(2):E63-E72.

REFERENZIERT VON
  1. Wu Shu-Ju, Liou Chian-Jiun, Chen Ya-Ling, Cheng Shu-Chen, Huang Wen-Chung, Fucoxanthin Ameliorates Oxidative Stress and Airway Inflammation in Tracheal Epithelial Cells and Asthmatic Mice, Cells, 10, 6, 2021. Crossref

  2. Mohibbullah Md., Haque Md. Nazmul, Sohag Abdullah Al Mamun, Hossain Md. Tahmeed, Zahan Md. Sarwar, Uddin Md. Jamal, Hannan Md. Abdul, Moon Il Soo, Choi Jae-Suk, A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights, Marine Drugs, 20, 5, 2022. Crossref

  3. Liu Chengcheng, Qi Wenwen, Teng Zhenxiao, Xu Runtong, Xi Yue, Qin Yiming, Xu Fenglei, Shi Lei, Zhao Miaoqing, Xia Ming, NGR-modified PEG-PLGA micelles containing Shikonin enhance targeting of dendritic cells for therapy of allergic rhinitis, International Immunopharmacology, 107, 2022. Crossref

  4. Han Bing, Ma Yu, Liu Yixiang, Fucoxanthin Prevents the Ovalbumin-Induced Food Allergic Response by Enhancing the Intestinal Epithelial Barrier and Regulating the Intestinal Flora, Journal of Agricultural and Food Chemistry, 70, 33, 2022. Crossref

  5. Lu Louise W., Gao Yao, Quek Siew-Young, Foster Meika, Eason Charles T., Liu Min, Wang Mingfu, Chen Jie-Hua, Chen Feng, The landscape of potential health benefits of carotenoids as natural supportive therapeutics in protecting against Coronavirus infection, Biomedicine & Pharmacotherapy, 154, 2022. Crossref

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