Erscheint 4 Ausgaben pro Jahr
ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537
Indexed in
Differential Modifying Effects of Food Additive Butylated Hydroxytoluene Toward Radiation and 4-Nitro-quinoline 1-Oxide−Induced Genotoxicity in Yeast
ABSTRAKT
The modifying effect of butylated hydroxytoluene (BHT) on 60Co gamma radiation and 4-nitro-quinoline 1-oxide-induced gene conversion and back mutation frequencies was investigated using diploid yeast Saccharomyces cerevisiae D7. Cells were exposed to 100 or 400 Gy in the presence of 0.025−0.25 mM BHT. BHT exhibited radioprotection and significantly reduced radiation-induced gene conversion and back mutation frequencies as well as cell killing. In another set of experiments, cells were simultaneously treated with 0.025−0.1 mM BHT and 0.5 μM 4-NQO. BHT significantly enhanced 4-NQO-induced gene conversion and back mutation frequencies. BHT post-treatment did not modify radiation-induced genetic events but enhanced 4-NQO-induced back mutation frequencies, indicating its potential to act as a tumor-promoting agent with 4-NQO.
-
Kim Wanyeon, Seong Ki Moon, Yang Hee Jung, Youn HyeSook, Youn BuHyun, Model Systems in Radiation Biology: Implication for Preclinical Study of Radiotherapy, Journal of Life Science, 22, 11, 2012. Crossref