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Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Spermatogonial Cytogenetic Toxicity of Vincristine and its Transmission in the Germline Cells of Swiss Mice

Volumen 21, Ausgabe 3, 2002, 9 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i3.60
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ABSTRAKT

We tested the anticancer drug vincristine sulfate (VCR) and cyclophosphamide (CTX) for their cytogenetic toxic effects on spermatogonia in Swiss mice, and we assessed the possible transmission of such effects in the germline cells. Spermatogonial metaphase chromosome aberration study, primary spermatocytic chromosome analysis, and sperm morphology assay were examined after a single intraperitoneal exposure of VCR 0.25, 0.5, and 1.0 mg/kg and CTX 40 mg/kg body weight at 24 hours, 4 weeks, and 8 weeks posttreatment, respectively. The induction of statistically significant percentages of aberrant Spermatogonial metaphases and chromosomal aberrations (excluding gaps) in the VCR-treated mice indicated its clastogenicity. The occurrence of significant percentages of aberrant primary spermatocytes with atypical bivalents and higher percentages of abnormal spermatozoa (sperm), although not statistically significant, indicated the transmission of the induced cytogenetic effects of VCR from spermatogonia to sperm. We conclude that VCR is genotoxic to the male germline cells of Swiss mice, and has the potential of transmitting the cytogenetic toxic effects to the next generation.

REFERENZIERT VON
  1. Dobrzyńska Małgorzata M., Czajka Urszula, Słowikowska Maria G., Reproductive effects after exposure of male mice to vincristine and to a combination of X-rays and vincristine, Reproduction, Fertility and Development, 17, 8, 2005. Crossref

  2. Drobnis Erma Z., Nangia Ajay K., Immunosuppressants and Male Reproduction, in Impacts of Medications on Male Fertility, 1034, 2017. Crossref

  3. Rencüzoğulları Eyyüp, Aydın Muhsin, Genotoxic and mutagenic studies of teratogens in developing rat and mouse, Drug and Chemical Toxicology, 42, 4, 2019. Crossref

  4. Delessard Marion, Saulnier Justine, Dumont Ludovic, Rives-Feraille Aurélie, Rives Nathalie, Rondanino Christine, Paradoxical risk of reduced fertility after exposure of prepubertal mice to vincristine or cyclophosphamide at low gonadotoxic doses in humans, Scientific Reports, 10, 1, 2020. Crossref

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