Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Journal of Environmental Pathology, Toxicology and Oncology
Impact-faktor: 1.241 5-jähriger Impact-Faktor: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2017024241
pages 277-281

DNA Damage in Wistar Rats Exposed to Organophosphate Pesticide Fenthion

Angélica Goldoni
Grupo de Pesquisa em Indicadores de Qualidade Ambiental, Universidade Feevale, Novo Hamburgo, RS, Brasil
Cláudia Regina Klauck
Grupo de Pesquisa em Indicadores de Qualidade Ambiental, Universidade Feevale, Novo Hamburgo, RS, Brasil
Julia Puffal
Grupo de Pesquisa em Indicadores de Qualidade Ambiental, Universidade Feevale, Novo Hamburgo, RS, Brasil
Patricia Grolli Ardenghi
Grupo de Pesquisa em Indicadores de Qualidade Ambiental, Universidade Feevale, Novo Hamburgo, RS, Brasil
Luciano Basso da Silva
Universidade Feevale

ABSTRAKT

In the last several decades, exposure to pesticides has become a concern to environmental and human health. Many pesticides are environmentally persistent and are characterized by varying degrees of toxicity and adverse effects, including DNA damage. The present study was undertaken to evaluate the genotoxic potential of organophosphate pesticide fenthion in Wistar rats, as assessed by the comet assay. Adult male Wistar rats were treated with a solution of fenthion at a concentration of 40 mg/kg/day, administered intraperitoneally for 18 consecutive days. Rats were killed 24 hours after the last pesticide administration, and the comet assay was performed in peripheral blood cells. The comet assay results revealed that the damage index (19.29 ± 3.59 vs. 7.80 ± 2.25) and the damage frequency (17.00 ± 3.46 vs. 7.5 ± 2.46) found in fenthion-treated rats were significantly higher than those found in the control group (p = 0.001 and p = 0.0006, respectively). The results show that fenthion affects the DNA integrity of rat cells and may induce DNA damage in exposed organisms.


Articles with similar content:

Protective Effect of Alstonia scholaris Against Radiation-Induced Clastogenic and Biochemical Alterations in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 2
Pradeep Kumar Goyal, Swafiya Jahan
Toxic Effects of Lead Exposure in Rats: Involvement of Oxidative Stress, Genotoxic Effect, and the Beneficial Role of N-Acetylcysteine Supplemented with Selenium
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 1
Samta Sharma, Bhanu Pratap Singh Raghuvanshi, Sangeeta Shukla
Dose-Dependent Effects of Ethanol on Lead-Induced Oxidative Stress in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 1
Swaran Flora, Pratibha Gautam, Nidhi Dwivedi
Naringenin, a Citrus Flavonoid, Ameliorates Arsenic-Induced Toxicity in Swiss Albino Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 3
Ruma Das, Avratanu Das, Sanjib Bhattacharya, Amrita Roy, Sagnik Haldar, Pallab Kanti Haldar
Protection of DNA From Ionizing Radiation-Induced Lesions by Asiaticoside
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 4
Saud Alarifi, Jisha Joy, Entissar Alsuhaibani, Cherupally Krishnan Krishnan Nair