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Journal of Environmental Pathology, Toxicology and Oncology
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ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i1.60
6 pages

Expression of p53 and Lactate Dehydrogenase in Murine Fibrosarcoma Following Exposure to g-Radiation

Khalida Wani
Radiation Oncology Division, Nanavathi Hospital and Medical Research Centre, Mumbai, India
Rema Rajagopalan
Radiation Biology Division, Bhabha Atomic Research Centre, Bombay, India
Nagaraj G. Huilgol
Radiation Oncology Division, Nanavathi Hospital and Medical Research Centre, Mumbai, India
Cherupally Krishnan Krishnan Nair
Mar Athanasious College for Advanced Studies, Tiruvalla, Tiruvalla, Kerala, India; St.Gregorios Dental College & Research Centre, Kothamangalam, Kerala, India

ABSTRAKT

Radiation-induced alterations in the levels of p53 and lactate dehydrogenase activities were studied in fibrosarcoma, following exposure to different doses of g-irradiation (2–10 Gy). The levels of p53 were elevated in the cytoplasm, while the lactate dehydrogenase activity in tumor tissue was considerably decreased.


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