Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Journal of Environmental Pathology, Toxicology and Oncology
Impact-faktor: 1.241 5-jähriger Impact-Faktor: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v29.i3.70
pages 245-253

Maternal Intake of N-nitroso Compounds from Cured Meat and the Risk of Pediatric Brain Tumors: A Review

Michael Huncharek
Division of Radiation Oncology, John Cochrane VA Medical Center, St. Louis, Department of Clinical Oncology, Marsh. eld Clinic Cancer Center, Marshfield, Wisconsin and Meta-Analysis Research Group, Stevens Point, Wisconsin


Experimental investigations conducted over the last several decades suggest that transplacental exposure of offspring to certain N-nitroso compounds (NOCs) results in the development of brain tumors in laboratory animals. Dietary cured meats are a recognized source of such exposures in humans, which raises the possibility that maternal consumption of cured meat products during pregnancy could increase the risk of childhood brain tumors. This hypothesis was first suggested by an observational study conducted by Preston-Martin et al. in 1982 supporting such a role in human disease. Since that time, additional epidemiological analyses have been performed addressing this hypothesis although results are inconsistent across studies. Due to the possible impact of bias and confounding in the available observational studies, the relatively weak effect seen in some observational analyses is of questionable validity. Nonetheless, since the association of transplacental NOC exposure and brain tumor risk is biologically plausible, the suspected association cannot be unequivocally dismissed. This paper reviews the current epidemiological evidence dealing with the maternal cured meat intake/childhood brain tumor association and suggests further avenues for research.

Articles with similar content:

Health Risks of Electromagnetic Fields. Part I: Evaluation and Assessment of Electric and Magnetic Fields
Critical Reviews™ in Biomedical Engineering, Vol.31, 2003, issue 3
Lynn M. Brodsky, William Leiss, Riadh W. Y. Habash, Daniel Krewski, Michael Repacholi
Hemiplegic Shoulder Pain: Diagnosis and Management
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.20, 2008, issue 3
John M. Vasudevan, Sridhar V. Vasudevan
Reconsidering Risk Groups: A Case of Ethical Reconstruction
Ethics in Biology, Engineering and Medicine: An International Journal, Vol.4, 2013, issue 3
Mark Tschaepe, Tibor Solymosi
NF-κB and Rheumatoid Arthritis: Will Understanding Genetic Risk Lead to a Therapeutic Reward?
Forum on Immunopathological Diseases and Therapeutics, Vol.4, 2013, issue 2
Robert Scheinman
Verruga Peruana: An Infectious Endemic Angiomatosis
Critical Reviews™ in Oncogenesis, Vol.6, 1995, issue 1
Ciro Maguina-Vargas, Roberto Patarca, Cecilia Sanguineti Diaz, Juan Rodriguez-!afur , Daniel Carrillo Ramos, Francisco Bravo-Puccio, Hector Caceres-Rios