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Journal of Environmental Pathology, Toxicology and Oncology
Impact-faktor: 1.241 5-jähriger Impact-Faktor: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v28.i3.70
pages 253-259

Effect of Indoor Air Pollution from Biomass Fuel Use on Argyrophilic Nuclear Organizer Regions in Buccal Epithelial Cells

Nandan Kumar Mondal
Artificial Organs Laboratory, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland; Department of Experimental Hematology, Chittaranjan National Cancer Institute, Kolkata, India; Department of Zoology, Kabi Nazrul College
Anindita Dutta
Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700 026, India
Anirban Banerjee
Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700 026, India
Sreeparna Chakraborty
Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700 026, India
Twisha Lahiri
Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700 026, India
Manas Ranjan Ray
Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700 026, India

ABSTRAKT

This study investigated the effect of indoor air pollution from biomass-fuel use on the expression of argyrophilic nucleolar organizer regions (AgNORs), an indicator of ribosome biosynthesis, in epithelial cells of oral mucosa. AgNORs were evaluated using cytochemical staining in 62 nonsmoking indian women (median age, 34 years), who cooked exclusively with biomass, and 55 age-matched women, who were from a similar neighborhood and cooked with relatively clean liquefied petroleum gas (LPG). Concentrations of particulate pollutants in indoor air were measured using a real-time aerosol monitor. Compared to the LPG-using controls, biomass-fuel users showed a remarkably increased number of AgNOR dots per nucleus (6.08 ± 2.26 vs 3.16 ± 0.86, p < 0.001), AgNOR size (0.85 ± 0.19 vs 0.53 ± 0.15 μm2, p < 0.001), and percentage of AgNOR-occupied nuclear area (4.88 ± 1.49 vs 1.75 ± 0.13%, p < 0.001). Biomass-using households had 2 to 4 times more particulate pollutants than that of LPG-using households. The changes in AgNOR expression were positively associated with PM10 and PM2.5 levels in indoor air after controlling for potential confounders such as age, kitchen location, and family income. Thus, biomass smoke appears to be a risk factor for abnormal cell growth via upregulation of ribosome biogenesis.

SCHLÜSSELWÖRTER: AgNOR, oral mucosa, biomass fuel, India

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