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第13届国际传热学会年报

ISBN 打印: 1-56700-226-9 (CD)
ISBN 在线: 1-56700-225-0

OXYGEN TRANSFER IN THE CEREBRAL TISSUE

DOI: 10.1615/IHTC13.p30.300
page 12

K. Tanishita
Faculty of Science and Technology, Keio University, Yokohama, Japan

K. Masamoto
Faculty of Science and Technology, Keio University, Yokohama, Japan

T. Negishi
Faculty of Science and Technology, Keio University, Yokohama, Japan

N. Takizawa
Center of Information Science, Kitasato University, Sagamihara, Japan

H. Kobayashi
School of Allied Health Science, Kitasato University, Sagamihara, Japan

Abstract

Oxygen delivery in the brain tissue is carried out by a convective-diffusion process determined by spatial inhomogeneity of partial pressure of oxygen (pO2). Previous studies identified inhomogeneous distribution of cerebral tissue pO2, which is related to spatial variations in microvascular structure, because large amount of oxygen is supplied from microvascular network. In this study, to evaluate the oxygen transport in cerebral cortex, we focused on regional structure of microvascular network and pO2 distribution in rat somatosensory cortex. To this end, firstly, we quantified three-dimensional microvascular structure by using confocal laser-scanning microscope (CLSM). Secondly, we characterized local tissue pO2 distribution by using an oxygen microelectrode. Finally, we discussed the possible feature of oxygen transfer in the cerebral tissue by numerical simulation of convective-diffusive process based on these experimental data (i.e., pO2 distribution and microvascular structure).

IHTC-13 Digital Library

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