RT Journal Article ID 7edd6f2c5ade7794 A1 Chi, Quanbo A1 Wang, Guoyi A1 Sheng, Yao A1 Xu, Wentao A1 Shi, Pengfei A1 Zhao, Changhui A1 Huang, Kunlun T1 Ethanolic Extract of the Golden Oyster Mushroom, Pleurotus citrinopileatus (Agaricomycetes), Alleviates Metabolic Syndrome in Diet-Induced Obese Mice JF International Journal of Medicinal Mushrooms JO IJM YR 2017 FD 2017-12-26 VO 19 IS 11 SP 1001 OP 1008 K1 glucose intolerance K1 medicinal mushrooms K1 metabolic disease K1 obesity K1 Pleurotus citrinopileatus AB Pleurotus citrinopileatus is an edible medicinal mushroom rich in biomolecules and thus has a high potential for use in formulating pharmaceutical and nutraceutical products. To test its effect on body weight and glucose control, we generated diet-induced obese (DIO) C57BL/6J male mice by feeding the mice a high-fat diet (60% fat) for 8 weeks and treating them with an ethanolic P. citrinopileatus extract (PCE) at either 200 or 500 mg/kg body weight for 12 additional weeks. The results showed that PCE significantly inhibited high-fat diet–induced weight gain, fat accumulation, and glucose intolerance in the DIO mice. Moreover, the PCE had a beneficial effect on liver and kidney function. On the basis of these results, we conclude that PCE is effective in the treatment of metabolic syndrome and thus could be a good candidate for use in future pharmaceutical or nutraceutical applications. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,3e829fa15c9a53be,7edd6f2c5ade7794.html