RT Journal Article ID 79eeeca109bedf13 A1 Leonhardt, Heinrich A1 Rahn, Hans-Peter A1 Cardoso, M. Cristina T1 Functional Links between Nuclear Structure, Gene Expression, DNA Replication, and Methylation JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 1999 FD 1999-12-20 VO 9 IS 3-4 SP 345 OP 351 K1 functional organization of the nucleus K1 targeting sequence K1 DNA methyltransferase K1 DNA ligase I K1 PCNA K1 chromatin structure. AB Over the last decades it became clear that mammalian nuclei are highly organized. Nuclear processes like DNA replication and RNA metabolism take place in distinct subnuclear foci, which are enriched for enzymes involved in the corresponding biochemical reactions. This colocalization of functions with their respective factors is often referred to as functional organization of the nucleus. This organization is achieved by assembly of different enzymes and regulatory factors into high-molecular-weight complexes that are tethered to insoluble nuclear structures. Recently, several links between nuclear structure, gene expression, DNA replication, and methylation have been described that illustrate the interrelation of higher-order structures and nuclear functions. New insights into the functional organization of the nucleus and how it could explain the high precision and overall coordination of nuclear processes are discussed. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,7831059776a36f5d,79eeeca109bedf13.html