%0 Journal Article %A Cheng, Wai-Yin %A Wei, Xue-Qin %A Siu, Ka-Chai %A Song, Ang-Xin %A Wu, Jian-Yong %D 2018 %I Begell House %K anticollagenase, antielastase, antioxidant, antityrosinase, Cordyceps sinensis, medicinal mushrooms and fungi, mycelial extract, Ophiocordyceps sinensis %N 7 %P 623-636 %R 10.1615/IntJMedMushrooms.2018026883 %T Cosmetic and Skincare Benefits of Cultivated Mycelia from the Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes) %U https://www.dl.begellhouse.com/journals/708ae68d64b17c52,640fd41946e8b89d,7578bfe17c9d40d4.html %V 20 %X Mushrooms are potential sources of novel natural cosmeceutical ingredients. This study was conducted to evaluate the cosmetic (skincare) benefits of the valuable medicinal species Ophiocordyceps sinensis (=Cordyceps sinensis). The mycelial extracts of 2 O. sinensis strains, Cs-HK1 and Cs-4, prepared sequentially with ethyl acetate, ethanol, and hot water were tested with in vitro assays for tyrosinase-, collagenase-, and elastase-inhibitory activity. The ethyl acetate extracts of both fungal strains showed potent antityrosinase and antielastase activity, with low half-maximal inhibitory concentrations (0.14-0.47 mg/mL) comparable to those of the respective reference compounds (arbutin and epigallocatechin gallate). All mycelial extracts exhibited moderate or significant anticollagenase activity; most extracts showed a significant photoprotective effect with a sun protection factor up to 25. The results from this study show the potential use of O. sinensis as a source of cosmetic ingredients for skincare applications. %8 2018-07-25