RT Journal Article ID 6f330b642d62ce90 A1 Ward , W. Steven A1 Zalensky, Andrei O. T1 The Unique, Complex Organization of the Transcriptionally Silent Sperm Chromatin JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 1996 FD 1996-09-30 VO 6 IS 2-3 SP 139 OP 147 K1 sperm chromatin K1 sperm nucleus K1 DNA structure AB The sperm nucleus contains one haploid copy of the genome that is completely transcriptionally silent and is not being replicated. Recent evidence has revealed that this "silent" chromatin nevertheless contains a complex organization at all levels. This includes DNA loop domain formation by the sperm nuclear matrix that is gene specific and highly ordered folding patterns of the chromosomes, particularly with respect to centromere and telomere positioning. Such specificity in the sperm DNA organization suggests functional requirements for their existence. As these begin to emerge, the sperm nucleus is becoming an important model for the study of the eukaryotic genome. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,0bb7e6fc4bc4aa76,6f330b642d62ce90.html