RT Journal Article
ID 6f2f050e17bd7858
A1 Kannan, Narayanan
A1 Sakthivel , Kunnathur Murugesan
A1 Guruvayoorappan, Chandrasekaran
T1 Nephroprotective Effect of Bauhinia tomentosa Linn against Cisplatin-Induced Renal Damage
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2016
FD 2016-07-28
VO 35
IS 2
SP 99
OP 107
K1 Bauhinia tomentosa
K1 nephrotoxicity
K1 cisplatin
K1 antioxidants
AB Cisplatin (CP) is an important chemotherapeutic drug used for the treatment of a wide variety of solid tumors. However, clinical use of CP has been limited due to its adverse effect of nephrotoxicity. In the present study, we evaluate the nephroprotective effect of Bauhinia tomentosa against CP-induced renal damage in rats. Administration of methonolic extract of B. tomentosa (250 mg/kg b.w.) results in a significant increase in antioxidant enzymes including superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT). Furthermore, treatment with B. tomentosa increased body weight and relative organ weight when compared with that of the CP-induced control group. Moreover, treatment with B. tomentosa extract significantly decreased lipid peroxidation(LPO), serum urea, and creatinine when compared with the CP-induced control group. Thus, the present study highlights the potential role of B. tomentosa and its use as a new protective strategy against CP-induced nephrotoxicity
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,1618a93b7a136570,6f2f050e17bd7858.html