RT Journal Article ID 6a14215061df9186 A1 Fajemiroye, James Oluwagbamigbe A1 MourĂ£o, Aline A. A1 Marques, Stefanne Madalena A1 Oliveira, Lanussy Porfiro de A1 Neto, Jeronimo Raimundo de Oliveira A1 Elusiyan, Abimbola Christanah A1 Pedrino, Gustavo Rodrigues A1 Costa, Elson Alves A1 da Cunha, Luiz Carlos A1 Zjawiony, Jordan K. T1 Preclinical Assessment of Cardiovascular Alterations Induced by Birch Polypore Mushroom, Piptoporus betulinus (Agaricomycetes) JF International Journal of Medicinal Mushrooms JO IJM YR 2017 FD 2017-05-05 VO 19 IS 3 SP 257 OP 265 K1 cardiovascular parameters K1 medicinal mushrooms K1 organic extract K1 Piptoporus betulinus K1 stigmasterol AB Piptoporus betulinus has been used in folk medicine for millennia. However, no data currently exist regarding its potential cardiovascular activity. In this work, the crude ethanolic extract and fractions (hexane, ethyl acetate, and water) with increased polarity from the partitioning process, as well as stigmasterol (the major metabolite isolated from P. betulinus), were administered orally at different doses to normotensive male Wistar rats an hour before recording mean arterial pressure, heart rate, renal blood flow, renal vascular conductance, arterial blood flow, and arterial vascular conductance. The acute oral administration of crude ethanolic extract and all fractions did not alter mean arterial pressure when compared with the control group, which received a vehicle. In addition, subchronic (14 days) oral administration of crude ethanolic extract, fractions, and stigmasterol did not alter cardiovascular parameters. In conclusion, our findings demonstrate that oral administration of organic extracts of P. betulinus did not induce cardiovascular alterations. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,2660055b0a219fef,6a14215061df9186.html