RT Journal Article
ID 6a14215061df9186
A1 Fajemiroye, James Oluwagbamigbe
A1 MourĂ£o, Aline A.
A1 Marques, Stefanne Madalena
A1 Oliveira, Lanussy Porfiro de
A1 Neto, Jeronimo Raimundo de Oliveira
A1 Elusiyan, Abimbola Christanah
A1 Pedrino, Gustavo Rodrigues
A1 Costa, Elson Alves
A1 da Cunha, Luiz Carlos
A1 Zjawiony, Jordan K.
T1 Preclinical Assessment of Cardiovascular Alterations Induced by Birch Polypore Mushroom, Piptoporus betulinus (Agaricomycetes)
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2017
FD 2017-05-05
VO 19
IS 3
SP 257
OP 265
K1 cardiovascular parameters
K1 medicinal mushrooms
K1 organic extract
K1 Piptoporus betulinus
K1 stigmasterol
AB Piptoporus betulinus has been used in folk medicine for millennia. However, no data currently exist regarding its potential cardiovascular activity. In this work, the crude ethanolic extract and fractions (hexane, ethyl acetate, and water) with increased polarity from the partitioning process, as well as stigmasterol (the major metabolite isolated from P. betulinus), were administered orally at different doses to normotensive male Wistar rats an hour before recording mean arterial pressure, heart rate, renal blood flow, renal vascular conductance, arterial blood flow, and arterial vascular conductance. The acute oral administration of crude ethanolic extract and all fractions did not alter mean arterial pressure when compared with the control group, which received a vehicle. In addition, subchronic (14 days) oral administration of crude ethanolic extract, fractions, and stigmasterol did not alter cardiovascular parameters. In conclusion, our findings demonstrate that oral administration of organic extracts of P. betulinus did not induce cardiovascular alterations.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,2660055b0a219fef,6a14215061df9186.html