RT Journal Article
ID 50fc876e3bf2ce39
A1 Zhang, Chun-Jing
A1 Gao, Xiulan
A1 Sun, Yan
A1 Sun, Xiaojie
A1 Wu, Yanmin
A1 Liu, Ying
A1 Yu, Haitao
A1 Cui, Guangcheng
T1 Anxiolytic Effects of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) on Ischemia-Induced Anxiety in Rats
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2015
FD 2015-01-26
VO 17
IS 1
SP 1
OP 10
K1 medicinal mushrooms
K1 Agaricus brasiliensis
K1 cerebral ischemic/reperfusion
K1 anxiety
K1 monoamine
K1 corticosterone
K1 extrapyramidal symptom
AB We investigated the anxiolytic effects Agaricus brasiliensis extract (AbSE) on ischemia-induced anxiety using the plus-maze test and the social interaction test. The animals were treated orally with AbSE (4, 8, and 10 mg/kg/d, respectively) for 30 d, followed by middle cerebral artery occlusion-induced cerebral ischemia. Levels of noradrenaline, dopamine, and serotonin in the cerebral cortex of rats, as well as oxidative stress and plasma corticosterone levels were analyzed, respectively. The rota-rod test was carried out to exclude any false positive results in experimental procedures related to anxiety disorders, and the catalepsy test was carried out to investigate whether AbSE induces catalepsy. Our results demonstrate that oral administration of AbSE presented anxiolytic-like effects in the elevated plus-maze test and the social interaction test. Furthermore, AbSE did not induce extrapyramidal symptoms in the catalepsy test. The mechanism underlying the anxiolytic effect of AbSE might be increased brain monoamine levels and plasma corticosterone levels and decreased oxidative stress in cerebral ischemia/reperfusion rats.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,4c4b67436894c345,50fc876e3bf2ce39.html