RT Journal Article ID 50fc876e3bf2ce39 A1 Zhang, Chun-Jing A1 Gao, Xiulan A1 Sun, Yan A1 Sun, Xiaojie A1 Wu, Yanmin A1 Liu, Ying A1 Yu, Haitao A1 Cui, Guangcheng T1 Anxiolytic Effects of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) on Ischemia-Induced Anxiety in Rats JF International Journal of Medicinal Mushrooms JO IJM YR 2015 FD 2015-01-26 VO 17 IS 1 SP 1 OP 10 K1 medicinal mushrooms K1 Agaricus brasiliensis K1 cerebral ischemic/reperfusion K1 anxiety K1 monoamine K1 corticosterone K1 extrapyramidal symptom AB We investigated the anxiolytic effects Agaricus brasiliensis extract (AbSE) on ischemia-induced anxiety using the plus-maze test and the social interaction test. The animals were treated orally with AbSE (4, 8, and 10 mg/kg/d, respectively) for 30 d, followed by middle cerebral artery occlusion-induced cerebral ischemia. Levels of noradrenaline, dopamine, and serotonin in the cerebral cortex of rats, as well as oxidative stress and plasma corticosterone levels were analyzed, respectively. The rota-rod test was carried out to exclude any false positive results in experimental procedures related to anxiety disorders, and the catalepsy test was carried out to investigate whether AbSE induces catalepsy. Our results demonstrate that oral administration of AbSE presented anxiolytic-like effects in the elevated plus-maze test and the social interaction test. Furthermore, AbSE did not induce extrapyramidal symptoms in the catalepsy test. The mechanism underlying the anxiolytic effect of AbSE might be increased brain monoamine levels and plasma corticosterone levels and decreased oxidative stress in cerebral ischemia/reperfusion rats. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,4c4b67436894c345,50fc876e3bf2ce39.html