RT Journal Article ID 3e1ca87d12de7a62 A1 Gupta, Gaurav A1 Chellappan, Dinesh Kumar A1 Kikuchi, Irene Satiko A1 Pinto, Terezinha de Jesus Andreoli A1 Pabreja, Kavita A1 Agrawal, Mohit A1 Singh, Yogendra A1 Tiwari, Juhi A1 Dua, Kamal T1 Nephrotoxicity in Rats Exposed to Paracetamol: The Protective Role of Moralbosteroid, a Steroidal Glycoside JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2017 FD 2017-06-20 VO 36 IS 2 SP 113 OP 119 K1 moralbosteroid K1 antioxidant K1 oxidative stress K1 nephrotoxicity K1 paracetamol AB Paracetamol (PCM) has an acceptable safety profile when used at prescribed doses. However, it is now understood that paracetamol can damage the kidneys when administered as an overdose. In addition, oxidative stress can play a major role in causing nephrotoxicity. This investigation studies the efficacy of moralbosteroid isolated from M. alba stem bark. Nephrotoxicity was induced with administration of paracetamol. Nephroprotection was studied using two doses of the extract. The experimental animals were divided into four groups (n = 6). Two groups served as positive and negative controls, respectively, and two received the test substances. All of the contents were orally administered. Significant reductions in nephrotoxicity and oxidative damages were observed in the treatment groups. There was a marked decrease in blood levels of urea, creatinine, and lipid peroxidation. Furthermore, it was found that glutathione levels in the blood increased dramatically after treatment. Histological findings confirmed the potent renoprotective potential of moralbosteroid. This was evidenced by the minimized intensity of nephritic cellular destruction. In animal studies, moralbosteroid exhibited dose-dependent activity, which is thought to be mediated through its antioxidant potential. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,07051ad6449b2804,3e1ca87d12de7a62.html