RT Journal Article
ID 3e1ca87d12de7a62
A1 Gupta, Gaurav
A1 Chellappan, Dinesh Kumar
A1 Kikuchi, Irene Satiko
A1 Pinto, Terezinha de Jesus Andreoli
A1 Pabreja, Kavita
A1 Agrawal, Mohit
A1 Singh, Yogendra
A1 Tiwari, Juhi
A1 Dua, Kamal
T1 Nephrotoxicity in Rats Exposed to Paracetamol: The Protective Role of Moralbosteroid, a Steroidal Glycoside
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2017
FD 2017-06-20
VO 36
IS 2
SP 113
OP 119
K1 moralbosteroid
K1 antioxidant
K1 oxidative stress
K1 nephrotoxicity
K1 paracetamol
AB Paracetamol (PCM) has an acceptable safety profile when used at prescribed doses. However, it is now understood that paracetamol can damage the kidneys when administered as an overdose. In addition, oxidative stress can play a major role in causing nephrotoxicity. This investigation studies the efficacy of moralbosteroid isolated from M. alba stem bark. Nephrotoxicity was induced with administration of paracetamol. Nephroprotection was studied using two doses of the extract. The experimental animals were divided into four groups (n = 6). Two groups served as positive and negative controls, respectively, and two received the test substances. All of the contents were orally administered. Significant reductions in nephrotoxicity and oxidative damages were observed in the treatment groups. There was a marked decrease in blood levels of urea, creatinine, and lipid peroxidation. Furthermore, it was found that glutathione levels in the blood increased dramatically after treatment. Histological findings confirmed the potent renoprotective potential of moralbosteroid. This was evidenced by the minimized intensity of nephritic cellular destruction. In animal studies, moralbosteroid exhibited dose-dependent activity, which is thought to be mediated through its antioxidant potential.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,07051ad6449b2804,3e1ca87d12de7a62.html