RT Journal Article ID 38c2647c2ab84a56 A1 VanderWaal, Robert A1 Wright, William D. A1 Roti , Joseph L. Roti T1 The Effects of Heat-Shock on Nuclear Matrix-Associated DNA-Replication Complexes JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 1999 FD 1999-12-20 VO 9 IS 3-4 SP 363 OP 371 K1 heat shock K1 nuclear matrix K1 DNA replication factories. AB To better understand the role of the nuclear matrix in heat-induced cell killing, we have investigated the effects of heat shock on DNA replication complexes. Changes in protein extractability are observed following heat shock, including stabilization of which stabilize DNA replication complexes in association with the nuclear matrix. This situation is accompanied by differential delays in the progress and completion of DNA synthesis and the transition from type I to type II DNA replication patterns. Interestingly, prolonged delays in restarting DNA synthesis produced significant protection from heat-induced cell killing. These results show that nuclear matrix-associated DNA replication complexes may be important targets for heat-induced cell killing. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,7831059776a36f5d,38c2647c2ab84a56.html