RT Journal Article
ID 28e8c12962efad64
A1 Hong, Ki Bae
A1 Hong, Sung-Yong
A1 Joung, Eun Young
A1 Kim, Byung Hee
A1 Bae, Song-Hwan
A1 Park, Yooheon
A1 Suh, Hyung Joo
T1 Hypocholesterolemic Effects of the Cauliflower Culinary-Medicinal Mushroom, Sparassis crispa (Higher Basidiomycetes), in Diet-Induced Hypercholesterolemic Rats
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2015
FD 2016-01-07
VO 17
IS 10
SP 965
OP 975
K1 medicinal mushrooms
K1 Sparassis crispa
K1 hypercholesterolemia
K1 cholesterol
K1 cholesterol 7α-hydroxylase
K1 3-hydroxy-3-methylglutaryl coenzyme A
AB The cauliflower culinary-medicinal mushroom, Sparassis crispa, possesses various biological activities that have been widely reported to have therapeutic applications. We examined the effects of S. crispa on serum cholesterol, hepatic enzymes related to cholesterol metabolism, and fecal sterol excretion in rats fed a cholesterol-rich diet for 4 weeks. Male Sprague-Dawley rats (8 weeks old) were randomly divided into 5 groups (n = 6 mice per group): normal diet (normal control [NC]), cholesterol-rich diet (cholesterol control [CC]), cholesterol-rich diet plus S. crispa fruiting body (SC), cholesterol-rich diet plus S. crispa extract (SCE), and cholesterol-rich diet plus S. crispa residue (SCR). SCE supplementation significantly enhanced hepatic cholesterol catabolism through the upregulation of cholesterol 7α-hydroxylase (CYP7A1) messenger RNA (mRNA) expression (2.55-fold compared with that in the NC group; P < 0.05) and the downregulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA expression (0.57-fold compared with that in the NC group; P < 0.05). Additionally, the SCE diet resulted in the highest fecal excretion of cholesterol and bile acid in hypercholesterolemic rats. In conclusion, mRNA expression of CYP7A1 and HMG-CoA reductase were significantly modulated by the absorption of SCE samples. Also, SCE samples had a significant effect on fecal bile acid and cholesterol excretion. These results suggest that SCE samples can induce hypocholesterolic effects through cholesterol metabolism and the reduction of circulating cholesterol levels.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,2fb21a9c4fd053ea,28e8c12962efad64.html