RT Journal Article
ID 23f36c8a47e5b757
A1 Yurkiv, Borys
A1 Wasser, Solomon P.
A1 Nevo, Eviatar D.
A1 Sybirna, Nataliya O.
T1 Antioxidant Effects of Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Higher Basidiomycetes): Evidence from Animal Studies
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2015
FD 2016-01-07
VO 17
IS 10
SP 943
OP 955
K1 medicinal mushrooms
K1 antioxidant enzymes
K1 diabetes mellitus
K1 leukocytes
K1 oxidative stress
AB With diabetes mellitus and increased glucose concentrations, the mitochondria electron transport chain is disrupted, superoxide anions are overproduced, and oxidative stress develops in cells. Thus, preventing oxidative stress can produce a decrease in the antioxidant system activity and an increase in apoptosis in immune cells. The application of medicinal mushrooms is a new possible approach to diabetes mellitus treatment. Therefore, the aim of this work was to investigate the influence of administration of the medicinal mushrooms Agaricus brasiliensis and Ganoderma lucidum on antioxidant enzyme activity in rat leukocytes. Wistar outbred white rats were used in the study. Streptozotocin was intraperitoneally injected once at a dose of 50 mg/kg body weight. Mushroom preparations were orally administered at a dose of 1 g/kg/day for 2 weeks. This revealed that in diabetes mellitus, the level of antioxidant enzyme activity is significantly decreased compared with control values, whereas the levels of lipid peroxidation is increased; this manifested in an increase in the amount of thiobarbituric acid reactive substances (TBARS). The medicinal mushrooms' administration is accompanied by an increase in antioxidant enzyme activity to control values and is even higher in the case of A. brasiliensis administration when compared with the diabetic group. As for the indicators of lipid peroxidation under mushroom administration of A. brasiliensis and G. lucidum, we observed a significant decrease of TBARS levels compared with the diabetic group. Increased activity of antioxidant enzymes and reduction of TBARS level indicate pronounced antioxidant properties of studied mushrooms.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,2fb21a9c4fd053ea,23f36c8a47e5b757.html