RT Journal Article ID 1c8f1f5f21a1d127 A1 Sadi, Gokhan A1 Kaya, Abdullah A1 Yalcin, Hicret Asli A1 Emsen, Bugrahan A1 Kocabas, Aytac A1 Kartal, Deniz Irtem A1 Altay, Ahmet T1 Wild Edible Mushrooms from Turkey as Possible Anticancer Agents on HepG2 Cells Together with Their Antioxidant and Antimicrobial Properties JF International Journal of Medicinal Mushrooms JO IJM YR 2016 FD 2016-03-09 VO 18 IS 1 SP 83 OP 95 K1 medicinal and edible mushrooms K1 HepG2 K1 cytotoxicity K1 antibacterial effect K1 antioxidants AB This study was designed to reveal cell growth inhibitory potential of six different edible mushrooms: Ramaria flava, Agrocybe molesta, Volvopluteus gloiocephalus, Lactarius deliciosus, Bovista plumbea, and Tricholoma terreum on HepG2 cells together with their antioxidant and antibacterial power. Methanolic extracts of V gloiocephalus and aqueous extracts of R. flava had the most potential cytotoxic effects over HepG2 cells. The best results for 2,2-diphenyl-1-picrylhydrazyl radical scavenging activities were obtained from both aqueous and methanolic extracts of R. flava. Methanolic extracts of T. terreum (IC50 = 1.62 mg/mL) and aqueous extracts of B. plumbea (IC50 = 0.49 mg/mL) showed maximum metal chelating activity. The highest reducing capacities were observed among the methanolic extracts of R. flava (EC50 = 1.65 mg/mL) and aqueous extracts of B. plumbea (EC50 = 1.71 mg/ mL). High-performance liquid chromatography analysis revealed the presence of many phenolic compounds in macrofungi; gallic acid and p-coumaric acid were the two main phenolics identified in all extracts. Antibacterial studies indicated that all six tested mushrooms showed antibacterial activity on at least three microorganisms. These results indicate that different extracts of the investigated mushrooms have considerable cytotoxic, antioxidant, and antibacterial properties and may be utilized as a promising source of therapeutics. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,33df00905b660ea5,1c8f1f5f21a1d127.html