%0 Journal Article %A Zhou, Shuai %A Liu, Yanfang %A Yang, Yan %A Tang, Qingjiu %A Zhang, Jingsong %D 2015 %I Begell House %K medicinal mushrooms, Coprinus comatus, fruiting body, polysaccharide, lymphocyte proliferation, hypoglycemic activity %N 10 %P 957-964 %R 10.1615/IntJMedMushrooms.v17.i10.50 %T Hypoglycemic Activity of Polysaccharide from Fruiting Bodies of the Shaggy Ink Cap Medicinal Mushroom, Coprinus comatus (Higher Basidiomycetes), on Mice Induced by Alloxan and Its Potential Mechanism %U https://www.dl.begellhouse.com/journals/708ae68d64b17c52,2fb21a9c4fd053ea,08d4e13d50321fd6.html %V 17 %X Three polysaccharide fractions from fruiting bodies of Coprinus comatus−CC30, CC60, and CC80−are obtained by water extraction and ethanol precipitation with ethanol percentages of 30%, 60%, and 80%, respectively. The hypoglycemic activity of the three fractions was tested based on mice with alloxan-induced diabetes. Results indicate that fraction CC60 is the most effective fraction in water extract from C. comatus; it can remarkably reduce the blood glucose concentration in 120 min at a dosage of 1000 mg/kg administered orally. It also presents a long-term hypoglycemic effect during 21 days of injection at the same dosage. This polysaccharide fraction provide a novel path to improve the treatment currently used for patients with diabetes. The data on mice spleen lymphocyte proliferation and protein tyrosine phosphatase 1B (PTP1B)−inhibiting activity of fractions indicate that the hypoglycemic activity of CC60 is possibly activated through immune stimulation, not PTP1B inhibition. %8 2016-01-07