每年出版 12 期
ISSN 打印: 1521-9437
ISSN 在线: 1940-4344
Indexed in
Water-Soluble Polysaccharides of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) Alleviate the Dose-Limiting Toxicities of Irinotecan (CPT-11)
摘要
Ganoderma lucidum extracts attenuated cisplatin-induced nausea and vomiting in rats. The clinical use of irinotecan (CPT-11) is hindered by dose-limiting diarrhea and myelosuppression. This study aimed to investigate whether a combination of G. lucidum polysaccharides (25 mg/kg by gavage) modulated the toxicities of CPT-11 in rats. The rat toxicity model was constructed by treatment of CPT-11 at 60 mg/kg/day by intravenous injection. Incidence of acute and delayed-onset diarrhea, blood cell counts, and body weight were monitored throughout the study. Administration of CPT-11 and a control vehicle (sterile water) for four days to rats induced a significant decrease in neutrophils and lymphocytes counts, body weight loss, and severe acute and delayed-onset diarrhea. These toxicities were suppressed when CPT-11 was combined with G. lucidum polysaccharides. Further study is needed to explore the mechanisms for the protective effect of G. lucidum polysaccharides against CPT-11 toxicity.
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LIANG ZENG-ENNI, YI YOU-JIN, GUO YU-TONG, WANG REN-CAI, HU QIU-LONG, XIONG XING-YAO, Inhibition of migration and induction of apoptosis in LoVo human colon cancer cells by polysaccharides from Ganoderma lucidum, Molecular Medicine Reports, 12, 5, 2015. Crossref