图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushr.v10.i4.40
pages 325-330

Effect of Culinary-Medicinal Lion's Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae), on Ethanol-Induced Gastric Ulcers in Rats

Mahmood Ameen Abdulla
Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Suzita Noor
University of Malaya
Kah-Hui Wong
Department of Anatomy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Mushroom Research Centre, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
Hapipah Mohd Ali
Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia

ABSTRACT

The cytoprotective effect of Hericium erinaceus freeze-dried fruiting bodies was investigated against ethanol-induced gastric mucosal injury in rats. Four groups of adult male Sprague Dawley rats were pretreated with distilled water (negative control), 250 mg kg−1 H. erinaceus, 500 mg kg−1 H. erinaceus, and omeprazole (positive control), respectively, before oral induction with absolute ethanol to generate gastric mucosal injury. Overall, rats pretreated with only distilled water suffered extensive hemorrhagic gastric mucosa lesions, whereas pretreatment with H. erinaceus or omeprazole reduced ulceration, with better cytoprotection observed in rats pretreated with omeprazole or 500 mg kg−1 H. erinaceus compared to rats pretreated with 250 mg kg−1 H. erinaceus. Histologically, marked damage was observed in the gastric mucosa, with submucosal edema and leucocyte infiltration in negative-control rats, whereas H. erinaceus-pretreated and positive-control rats had less gastric mucosal damage, decreased edema, and no submucosal leucocyte infiltration. In conclusion, H. erinaceus provided cytoprotection against ethanol-induced gastric ulcers in rats.


Articles with similar content:

Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Akbar Masood, Ovais Zargar, Mohammad Afzal Zargar, Showkat Ahmad Ganie, Shajrul Amin, Parvaiz Ahmad Dar, Shayaq Ul Abeer, Rabia Hamid, Tanveer Ali Dar, Bilal Zargar
Investigation of the Tiger Milk Medicinal Mushroom, Lignosus rhinocerotis (Agaricomycetes), as an Antiulcer Agent
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 12
Szu Ting Ng, Chon Seng Tan, Chia Yoong Chang, Kar Lin Nyam
Radioprotection by Oral Administration of Aegle marmelos (L.) Correa In Vivo
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 4
Ponemone Venkatesh, Ganesh Chandra Jagetia
Curative Effect of Amorphophallus campanulatus (Roxb.) Blume. Tuber On N-Nitrosodiethylamine- Induced Hepatocellular Carcinoma in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 3
Santhibhavan Prabhakaran Prabha, Anand Nitha, Puthuparampil Nazarudeen Ansil, Mukalel Sankunni Latha
Nephrotoxicity in Rats Exposed to Paracetamol: The Protective Role of Moralbosteroid, a Steroidal Glycoside
Journal of Environmental Pathology, Toxicology and Oncology, Vol.36, 2017, issue 2
Gaurav Gupta, Kamal Dua, Kavita Pabreja, Yogendra Singh, Terezinha de Jesus Andreoli Pinto, Juhi Tiwari, Dinesh Kumar Chellappan, Mohit Agrawal, Irene Satiko Kikuchi