图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v19.i6.20
pages 499-507

Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Modulates Purinoceptor-Coupled Calcium Signaling and Murine Nociceptive Behavior

Pei-Shan Liu
Department of Microbiology, Soochow University, Taipei, Taiwan, ROC
Sheau-Huei Chueh
Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, ROC
Chin-Chu Chen
Bioengineering Center, Grape King Bio Ltd, Taoyuan City, Taiwan; Department of Food Science, Nutrition and Nutraceutical Biotechnology, Shih Chien University, Taipei City, Taiwan; Institute of Biotechnology, National Changhua University of Education, Changhua County, Taiwan
Li-Ya Lee
Department of Medical Research, E-Da Hospital, Kaohsiung, Taiwan, ROC
Li-Yen Shiu
Department of Medical Research, E-Da Hospital, Kaohsiung, Taiwan, ROC

ABSTRACT

Hericium erinaceus is well known for the neurotrophic effect it confers by promoting nerve growth factor biosynthesis. We discovered a novel bioactivity of H. erinaceus in its ability to suppress adenosine triphosphate (ATP)–induced calcium signaling in neuronal PC12 cells. ATP, known primarily as a neurotransmitter, also acts on purinoceptors (P2 purinergic receptor [P2R]) to generate the cellular calcium signaling and secretion that mediate P2R physiological manifestations, including pain. Chronic pain reduces quality of life. However, constant analgesic administration can cause liver and kidney injury, as well as loss of the analgesic effect because of desensitization. In this study we investigated the analgesic potential of H. erinaceus through measurements of ATP-induced Ca2+ signaling in cell lines and observation of pain behaviors in mice. In P2R-coupled Ca2+ signaling measurements, extracts of H. erinaceus mycelia (HEEs) blocked ATP-induced Ca2+ signaling in both rat PC12 cells and human HOS cells. HEEs completely blocked ATP-induced Ca2+ signaling in human HOS cells, suggesting that this effect of HEEs is exerted through the P2R subtypes present in HOS cells, which include the P2X4, P2X7, P2Y2, and P2Y4 subtypes. In observations of animal behavior during pain, HEEs significantly reduced heat-induced pain, including postponing both the tail-flick response to heat stimulation and the paw-lifting response to a hot plate. This study demonstrates novel characteristics of H. erinaceus in reducing nociceptive behavior and blocking the functional activity of P2R. Further studies are required to verify this linkage and its molecular mechanisms.


Articles with similar content:

Neurotropic and Trophic Action of Lion's Mane Mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) Extracts on Nerve Cells in Vitro
International Journal of Medicinal Mushrooms, Vol.9, 2007, issue 1
Mykhaylo Moldavan, Burkhard Kirchhoff, Paola Pedarzani, Andriy P. Grygansky, Olena V. Kolotushkina, Galina G. Skibo
Neuroanatomical and Pharmacological Evidence for a Functional Interaction Between GABAergic and NPY-Y1 Transmission in the Amygdala of Y1R/LacZ Transgenic Mice
Critical Reviews™ in Neurobiology, Vol.16, 2004, issue 1&2
Paolo Mele, Mariangela Serra, Gian Carlo Panzica, Alessandra Oberto, Maria Giuseppina Pisu, Carola Eva
Lion's Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 11
Snehlata Samberkar, Kah-Hui Wong, Sivasangkary Gandhi, Jegadeesh Raman, Murali Naidu, Vikineswary Sabaratnam
Dietary Supplementation of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), and Spatial Memory in Wild-Type Mice
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 5
Daniela Ratto, Valentina Cesaroni, Federico Brandalise, Carolina Girometta, Veralice Lanaia, Elena Savino, Germano Orrù, Paola Rossi, Fabio Perrucci, Alessandra Occhinegro
Molecular and Cellular Mechanisms for the Polarized Sorting of Serotonin Receptors: Relevance for Genesis and Treatment of Psychosis
Critical Reviews™ in Neurobiology, Vol.16, 2004, issue 4
Zongqi Xia, Bryan L. Roth