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ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Assessment of the Safety of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), in Rats: Biochemical, Hematological, and Antioxidative Parameters

卷 18, 册 10, 2016, pp. 861-870
DOI: 10.1615/IntJMedMushrooms.v18.i10.20
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摘要

Lentinus edodes is an edible mushroom studied for use, or as an adjunct, in the prevention of illnesses such as hypertension, hypercholesterolemia, diabetes, and cancer. Despite the functional properties of L. edodes, the doses commonly reported in experimental studies are much higher than those actually consumed. Thus, we aimed to establish the optimum intake levels of L. edodes in vivo. Four groups of male Wistar rats received dry and powdered L. edodes reconstituted in water for 30 days: control (water only), L. edodes 100 mg/kg, L. edodes 400 mg/kg, and L. edodes 800 mg/kg. Biochemical and hematological parameters were assessed using commercial kits. Antioxidant parameters were quantified spectrophotometrically. Neither cholesterol, triglycerides, glucose, nor transaminase activity was different among any of the L. edodes concentrations. However, fructosamine concentrations were significantly decreased in groups consuming L. edodes at 100 or 400 mg/kg. A significant decrease in hemoglobin concentration was found in the 400 and 800 mg/kg/day L. edodes groups, and leukopenia occurred in rats that consumed L. edodes 800 mg/kg/day compared with the control group. L. edodes at 100 and 400 mg/kg increased amounts of reduced glutathione compared with the control group. L. edodes was effective as an antioxidant at 100 and 400 mg/kg, but at 400 and 800 mg/kg some disturbances were observed, such as reductions in hemoglobin and leukocytes. In summary, this study has potential benefits for scientific development because the safe daily intake of L. edodes (at 100 mg/kg) is, to our knowledge, reported for the first time in a preclinical study.

对本文的引用
  1. Amirullah Nur Amalina, Zainal Abidin Nurhayati, Abdullah Noorlidah, The potential applications of mushrooms against some facets of atherosclerosis: A review, Food Research International, 105, 2018. Crossref

  2. Shibu Marthandam Asokan, Agrawal Dinesh Chandra, Huang Chih-Yang, Mushrooms: A Pandora Box of Cardioprotective Phytochemicals, in Medicinal Plants and Fungi: Recent Advances in Research and Development, 4, 2017. Crossref

  3. Yang Hye, Kim Min, Kwon Dae, Kim Da, Zhang Ting, Ha Chulgyu, Park Sunmin, Combination of Aronia, Red Ginseng, Shiitake Mushroom and Nattokinase Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats, Nutrients, 10, 7, 2018. Crossref

  4. Badalyan Susanna M., Barkhudaryan Anush, Rapior Sylvie, Recent Progress in Research on the Pharmacological Potential of Mushrooms and Prospects for Their Clinical Application, in Medicinal Mushrooms, 2019. Crossref

  5. Laurino Leticia, Viroel Fabia, Caetano Erika, Spim Sara, Pickler Thaisa, Rosa-Castro Raquel, Vasconcelos Edilma, Jozala Angela, Hataka Alessandre, Grotto Denise, Gerenutti Marli, Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus, Nutrients, 11, 11, 2019. Crossref

  6. Ma Lin , Huo Chun‑Yan , Zhang Xiao‑Yu , Qin Chen‑Qiang , Ren Di‑Feng , Lu Jun , Protective effect of Letinous�edodes foot peptides against ethanol‑induced liver injury in L02 cells, Molecular Medicine Reports, 2018. Crossref

  7. Atila F., Cultivation and Utilization of Shiitake Mushroom, in Medicinal Plants, 28, 2021. Crossref

  8. Viroel Fabia Judice Marques, Laurino Leticia Favara, Caetano Érika Leão Ajala, Jozala Angela Faustino, Spim Sara Rosicler Vieira, Pickler Thaisa Borim, Sercundes Michelle Klein, Gomes Marcela C., Hataka Alessandre, Grotto Denise, Gerenutti Marli, Ganoderma lucidum Modulates Glucose, Lipid Peroxidation and Hepatic Metabolism in Streptozotocin-Induced Diabetic Pregnant Rats, Antioxidants, 11, 6, 2022. Crossref

  9. NIE Yuanyang, JIA Yajuan, ZHANG Xiunan, LU Sen, LI Bo, Screening of mixed lactic acid bacteria starter and its effects on the quality and flavor compounds of fermented Lentinus edodes, Food Science and Technology, 42, 2022. Crossref

  10. Kok Kee Wong, Hock Ong Ghim, Yee Sabrina Ling Shuet, Er Loh Kyle, Application of Fungi as Meat Alternatives in Industry: Mini Review, Journal of Experimental Biology and Agricultural Sciences, 10, 4, 2022. Crossref

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