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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v17.i6.20
pages 511-520

Depigmenting Effect of Winter Medicinal Mushroom Flammulna velutipes (Higher Basidiomycetes) on Melanoma Cells

Reiko Nagasaka
Department of Food Science and Technology, Graduate School of Marine Science and Technology, Konan 5-4-7, Minato-ku, Tokyo 108-8477, Japan
Yuki Ishikawa
Department of Food Science and Technology, Graduate School of Marine Science and Technology, Konan 5-4-7, Minato-ku, Tokyo 108-8477, Japan
Takumi Inada
Department of Food Science and Technology, Graduate School of Marine Science and Technology, Konan 5-4-7, Minato-ku, Tokyo 108-8477, Japan
Toshiaki Ohshima
Department of Food Science and Technology, Graduate School of Marine Science and Technology, Konan 5-4-7, Minato-ku, Tokyo 108-8477, Japan

ABSTRACT

In humans, skin pigmentation results from the biochemichal synthesis and accumulation of melanin. We previously revealed that edible winter mushroom Flammulina velutipes extract inhibited melanosis in commercially available edible crustacea. Therefore, the current study was conducted to find if edible mushrooms extracts are useful for the skin whitening and the underlying mechanisms in melanin biosynthesis. Tyrosinase is one of the key enzymes for melanin biosynthesis. This study demonstrated that melanin synthesis and tyrosinase activity were suppressed by the F. velutipes extracts in B16 murine melanoma cells through the slow expression of microphthalmia-associated transcription factor. These results suggested that the F. velutipes extract could contain an effective component in whitening cosmetics and an alternative therapeutic agent for treating hyperpigmentation.


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