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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v17.i6.10
pages 501-509

Isolation and Characterization of Bioactive Metabolites from Fruiting Bodies and Mycelial Culture of Ganoderma oerstedii (Higher Basidiomycetes) from Mexico

Guillermo Mendoza
Laboratorio de Alta Tecnologia de Xalapa, Universidad Veracruzana, Xalapa, Veracruz, México; Facultad de Ciencias Agricolas, Universidad Veracruzana, Xalapa, Veracruz, México
Jorge Suarez-Medellin
Centro de Investigaciones Cerebrales (CICE), Universidad Veracruzana. Av. Dr. Luis Castelazo Ayala s/n, Colonia Industrial Animas, 9119, Xalapa, Veracruz, Mexico
Cesar Espinoza
Laboratorio de Alta Tecnologia de Xalapa (LATEX), Universidad Veracruzana. Calle Medicos 5, Unidad del Bosque, 91010, Xalapa, Veracruz, Mexico
Angel Ramos-Ligonio
LADISER Inmunologia y Biología Molecular, Facultad de Ciencias Quimicas, Universidad Veracruzana, Orizaba, Veracruz, México; Centro de Investigaciones Biomédicas, Universidad Veracruzana, Luis Castelazo, Animas, Xalapa, Veracruz, México
Jose J. Fernandez
Instituto Universitario de Bio-Organica "'Antonio Gonzalez"', Universidad de La Laguna, Astrofisico Francisco Sanchez 2, 38206, La Laguna, Tenerife, Spain
Manuel Norte
Instituto Universitario de Bio-Organica "'Antonio Gonzalez"', Universidad de La Laguna, Astrofisico Francisco Sanchez 2, 38206, La Laguna, Tenerife, Spain
Ángel Trigos
Centro de Investigaciones Biomédicas, Universidad Veracruzana, Luis Castelazo, Animas, Xalapa, Veracruz, México; Laboratorio de Alta Tecnologia de Xalapa, Universidad Veracruzana, Xalapa, Veracruz, México

ABSTRACT

Various species of the genus Ganoderma have been used for centuries according to oriental tradition as a source of medicines and nutrients. A chemical study of the fruiting bodies and mycelial culture of G. oerstedii was carried out with the idea of isolating and characterizing active natural components present to make use of their potential pharmaceutical application in Mexico. The fruiting bodies and mycelial culture of G. oesrtedii were lyophylized and extracted one after the other with hexane, chloroform, and methanol. Following this process, each substance was extracted separately by using column chromatography. From fruiting bodies eight metabolites, five sterols (ergosta-7,22-dien-3β-ol, ergosterol peroxide, ergosterol, cerevisterol, and ergosta-7,22-dien-3-one) as well as three terpene compounds (ganodermanondiol, ganoderic acid Sz, and ganoderitriol M) were obtained from fruiting bodies. From the mycelial culture three metabolites, two sterols (ergosterol and cerevisterol), and a new terpene compound (ganoderic acetate from the acid) were obtained. These structures were established based on a spectroscopic analysis mainly using nuclear magnetic resonance and a comparison with data already established.


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