每年出版 12 期
ISSN 打印: 1521-9437
ISSN 在线: 1940-4344
Indexed in
Effects of Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes), Polysaccharide Extract in Streptozotocin-Induced Diabetic Rats
摘要
In this article we report the healing effects of a Phellinus linteus fruiting body hot water extract (PLE) in streptozotocin (STZ)−induced diabetic rats. PLE was given before and after STZ. The preprotective, protective, and postprotective effects of PLE on STZ-induced oxidative stress were studied using biochemical (caspase 3 activity, cytosolic-to-lysosomal ratio of cathepsin B and L, DNA fragmentation levels), ordinary histological and immuno-histochemical investigation parameters. Following oral administration of PLE after STZ application, the serum glucose concentration significantly decreased up to 41.13% compared with the control group (P < 0.05). The hypoglycemic potential of the PLE was further supported by an increase of insulin secretion in the islets of Langerhans. In addition, the number of cells in Langerhans islets increased by 45.89% when PLE was given after STZ application. On the other hand, the use of PLE before oxidative stress could not prevent the onset of diabetes. This is, to our knowledge, the first study of the effect of application time of orally administered Ph. Linteus hot water extract on STZ-induced diabetes.
-
Arcella Antonietta, Oliva Maria Antonietta, Sanchez Massimo, Staffieri Sabrina, Esposito Vincenzo, Giangaspero Felice, Cantore Giampaolo, Effects of hispolon on glioblastoma cell growth, Environmental Toxicology, 32, 9, 2017. Crossref
-
Gargano Maria Letizia, van Griensven Leo J. L. D., Isikhuemhen Omoanghe S., Lindequist Ulrike, Venturella Giuseppe, Wasser Solomon P., Zervakis Georgios I., Medicinal mushrooms: Valuable biological resources of high exploitation potential, Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, 151, 3, 2017. Crossref
-
Feng Han, Zhang Shijie, Wan Jennifer Man-Fan, Gui Lifeng, Ruan Mengcheng, Li Na, Zhang Hongyu, Liu Zhiguo, Wang Hualin, Polysaccharides extracted from Phellinus linteus ameliorate high-fat high-fructose diet induced insulin resistance in mice, Carbohydrate Polymers, 200, 2018. Crossref
-
Mingyi Yang, Belwal Tarun, Devkota Hari Prasad, Li Li, Luo Zisheng, Trends of utilizing mushroom polysaccharides (MPs) as potent nutraceutical components in food and medicine: A comprehensive review, Trends in Food Science & Technology, 92, 2019. Crossref
-
Liu Yangyang, Wang Chaorui, Li Jinshan, Mei Yuxia, Liang Yunxiang, Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes, Nutrients, 11, 2, 2019. Crossref
-
Badalyan Susanna M., Barkhudaryan Anush, Rapior Sylvie, Recent Progress in Research on the Pharmacological Potential of Mushrooms and Prospects for Their Clinical Application, in Medicinal Mushrooms, 2019. Crossref
-
Liang Chih-Hung, Wu Chiu-Yeh, Ho Wai-Jane, Liang Zeng-Chin, Influences of carbon and nitrogen source addition, water content, and initial pH of grain medium on hispidin production of Phellinus linteus by solid-state fermentation, Journal of Bioscience and Bioengineering, 130, 6, 2020. Crossref
-
Chowdhury Pritha, Paul Santanu, The Potential Role of Mushrooms in The Prevention and Treatment of Diabetes: A Review, Journal of Biologically Active Products from Nature, 10, 5, 2020. Crossref
-
Arcella Antonietta, Sanchez Massimo, Natural substances to potentiate canonical glioblastoma chemotherapy, Journal of Chemotherapy, 33, 5, 2021. Crossref
-
Wu Chiu-Yeh, Liang Chih-Hung, Ou Chin-Hao, Liang Zeng-Chin, Zinc ion addition to grain media enhanced hispidin production during solid-state fermentation of Phellinus linteus, Journal of the Taiwan Institute of Chemical Engineers, 121, 2021. Crossref
-
Kapri Mandira, Srivastav Prem Prakash, Sharma Satyawati, Mushroom as a Source of Fungal Based Functional Foods, in Functional Foods, 2022. Crossref
-
Xia Yongjun, Yang Caiyun, Liu Xiaofeng, Wang Guangqiang, Xiong Zhiqiang, Song Xin, Yang Yijin, Zhang Hui, Ai Lianzhong, Enhancement of triterpene production via in situ extractive fermentation of Sanghuangporus vaninii YC‐1 , Biotechnology and Applied Biochemistry, 2022. Crossref
-
Ajith Thekkuttuparambil A., Janardhanan Kainoor K., Antidiabetic Properties of Medicinal Mushrooms with Special Reference to Phellinus Species: A Review, The Natural Products Journal, 11, 2, 2021. Crossref