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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.2020034229
pages 445-453

Effect of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Capsules on Colistin-Induced Nephrotoxicity

Gamze Talih
Department of Anesthesiology, School of Medicine, Bozok University, Yozgat, Turkey
Çiğdem Ünal Kantekin
Department of Anesthesiology, School of Medicine, Bozok University, Yozgat, Turkey
Yeşim Göçmen
Department of Biochemistry, School of Medicine, Bozok University, Yozgat, Turkey
Sevinç Çelik
Department of Pathology, School of Medicine, Bozok University, Yozgat, Turkey
Tutkun Talih
Department of General Surgery, Erciyes University, Medical Faculty, Kayseri, Turkey
Aliye Esmaoğlu
Department of Anesthesiology, Erciyes University, Medical Faculty, Kayseri, Turkey

ABSTRACT

The aim of this experimental study was to investigate the protective effect of Ganoderma lucidum capsules against colistin nephrotoxicity. The study animals were separated into four groups: control, colistin (9 mg/kg), colistin−G. lucidum 50 mg/kg, and colistin−G. lucidum 100 mg/kg. In the colistin group, serum blood urea nitrogen and creatinine values were found to be higher than those of the other groups (p < 0.001). The malondialdehyde, catalase, total oxidative stress, oxidative stress index, and oxidized glutathione values in serum and kidney tissue samples were determined to be higher in the colistin group than in the other groups (p < 0.001). The total antioxidative stress, superoxide dismutase, glutathione peroxidase, and glutathione values measured in the serum and kidney tissue samples were determined to be lower in the colistin group (p < 0.001). Oxidative stress is responsible for tubule damage in colistin nephrotoxicity, and when G. lucidum is used together with colistin, renal damage is reduced.

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