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The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Isolation, Purification, and Immunological Activities of a Low-Molecular-Weight Polysaccharide from the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes)

卷 15, 册 4, 2013, pp. 407-414
DOI: 10.1615/IntJMedMushr.v15.i4.80
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摘要

To obtain a low-molecular-weight polysaccharide with immuno-enhancing activity, hot water extract of Ganoderma lucidum fruit bodies was separated by membrane ultrafiltration, anion exchange, and gel filtration chromatography, and the immunological activities of fractions were assessed on the basis of nitric oxide production by RAW 264.7 macrophages. A novel polysaccharide (TB3-2-2) was successfully isolated and purified. TB3-2-2 is a homogeneous polysaccharide, with a relative molecular weight of 5.11 × 103 Da, identified by high-performance liquid chromatography and was composed of galactose and glucose in a molar ratio of 2:3 determined by high-performance anion exchange chromatography. TB3-2-2 had a carbohydrate content of 99%, as measured using the phenol-sulfuric acid method. Proliferation of mouse spleen lymphocytes and the expression level of interleukin-6 was significantly increased by TB3-2-2. Results indicate that the low-molecular-weight polysaccharide with immunological activity in G. lucidum is worthy of further research and development.

对本文的引用
  1. Siwulski Marek, Sobieralski Krzysztof, Golak-Siwulska Iwona, Sokół Sławomir, Sękara Agnieszka, Ganoderma lucidum (Curt.: Fr.) Karst. – health-promoting properties. A review, Herba Polonica, 61, 3, 2015. Crossref

  2. Sui Xiao-chen, Guo Qing-bin, Xia Yong-mei, Cui Steve W., Shen Jie, Zhang Jue, Ding Zhong-yang, Structure features of the intracellular polysaccharide from Ganoderma lucidum and the irrelative immune-anticancer activities of GLPs, Bioactive Carbohydrates and Dietary Fibre, 8, 2, 2016. Crossref

  3. Zhang Jiao-Jiao, Li Ya, Zhou Tong, Xu Dong-Ping, Zhang Pei, Li Sha, Li Hua-Bin, Bioactivities and Health Benefits of Mushrooms Mainly from China, Molecules, 21, 7, 2016. Crossref

  4. Cör Darija, Knez Željko, Knez Hrnčič Maša, Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review, Molecules, 23, 3, 2018. Crossref

  5. Zhu Fengmei, Du Bin, Xu Baojun, Preparation and Characterization of Polysaccharides from Mushrooms, in Polysaccharides, 2015. Crossref

  6. Zhu Fengmei, Du Bin, Xu Baojun, Preparation and Characterization of Polysaccharides from Mushrooms, in Polysaccharides, 2014. Crossref

  7. Turło Jadwiga, The biotechnology of higher fungi - current state and perspectives, Folia Biologica et Oecologica, 10, 2014. Crossref

  8. Lu Jiahui, He Rongjun, Sun Peilong, Zhang Fuming, Linhardt Robert J., Zhang Anqiang, Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review, International Journal of Biological Macromolecules, 150, 2020. Crossref

  9. He Jiaming, Zhang Wenkan, Di Tuoyu, Meng Jiahong, Qi Yiying, Li Guoqi, Zhang Yuxiang, Su Hang, Yan Weiqi, Water extract of sporoderm-broken spores of Ganoderma lucidum enhanced pd-l1 antibody efficiency through downregulation and relieved complications of pd-l1 monoclonal antibody, Biomedicine & Pharmacotherapy, 131, 2020. Crossref

  10. Wang Ting, Wang Yihong, Chen Chen, Ren Ang, Yu Hanshou, Zhao Mingwen, Effect of the heme oxygenase gene on mycelial growth and polysaccharide synthesis in Ganoderma lucidum , Journal of Basic Microbiology, 61, 3, 2021. Crossref

  11. Kothari Damini, Patel Seema, Kim Soo-Ki, Anticancer and other therapeutic relevance of mushroom polysaccharides: A holistic appraisal, Biomedicine & Pharmacotherapy, 105, 2018. Crossref

  12. Adeeyo Adeyemi O., Alabi Mercy A., Bamigboye Comfort O., Adeeyo Rebecca O., Odiyo John O., , 73, 2022. Crossref

  13. Abo Nahas Hebatallah H., Darwish Amira Mohamed Galal, Abo Nahas Yousef H., Elsayed Mervet. A., Abdel-Azeem Mohamed A., Abdel-Azeem Ahmed M., Fungi as a Gold Mine of Antioxidants, in Industrially Important Fungi for Sustainable Development, 2021. Crossref

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