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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.2017024522
pages 967-980

Antioxidant and Genotoxic Properties of Hispidin Isolated from the Velvet-Top Mushroom, Phaeolus schweinitzii (Agaricomycetes)

Lina Smolskaite
Department of Food Science and Technology, Kaunas University of Technology, Kaunas, Lithuania
Gražina Slapšyte
Institute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania
Jurate Mierauskiene
Institute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania
Veronika Dedonyte
Institute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania
Petras Rimantas Venskutonis
Department of Food Science and Technology, Kaunas University of Technology, Kaunas, Lithuania

ABSTRACT

Antioxidant and genotoxic properties of hispidin isolated from the Phaeolus schweinitzii mushroom were evaluated with various assays. Hispidin demonstrated strong free radical scavenging, oxygen radical absorbance capacity, and ferric-reducing antioxidant power; in all applied assays, hispidin exhibited antioxidant capacity similar to or higher than that of the reference antioxidant Trolox. Genotoxic activity of hispidin was assessed using different end points: chromosome aberrations, micronuclei, sister chromatid exchanges, and primary DNA damage (detected by the comet assay) in human lymphocytes in vitro, and gene mutations in the Salmonella/microsome test. Hispidin did not increase the frequency of chromosome aberrations, micronuclei, or primary DNA damage in human lymphocytes in vitro and did not produce reverse mutation in bacterial cells. However, we identified in human lymphocytes a statistically significant dose-dependent increase in sister chromatid exchange frequency and a decrease in replication index and nuclear division index values.


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