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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.2020034864
pages 535-546

Antioxidant and Anti-Inflammatory Potential of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Sporophores from Various Culture Conditions

Ibrahima Diallo
Laboratoire de Pharmacologie et Physiopathologie Expérimentale, UMR Qualisud, CIRAD–Université de Montpellier, Montpellier, France; Laboratoire de Botanique, Phytochimie et Mycologie, CEFE, CNRS-Université de Montpellier-Université Paul-Valéry Montpellier–EPHE–IRD, Montpellier, France; Laboratoire de Technologie Alimentaire du Département de Génie Chimique de l'Université Gamal Abdel Nasser de Conakry, BP 1147, Conakry, Guinée
Frédéric Boudard
Laboratoire d'Immunologie, UMR Qualisud, CIRAD–Université de Montpellier, Montpellier, France
Sylvie Morel
Laboratoire de Botanique, Phytochimie et Mycologie, CEFE, CNRS–Université de Montpellier–Université Paul-Valéry Montpellier–EPHE–IRD, Montpellier, France
Manon Vitou
Laboratoire de Botanique, Phytochimie et Mycologie, CEFE, CNRS–Université de Montpellier–Université Paul-Valéry Montpellier–EPHE–IRD, Montpellier, France
Caroline Guzman
Laboratoire d'Immunologie, UMR Qualisud, CIRAD–Université de Montpellier, Montpellier, France
Nathalie Saint
PHYMEDEXP, Université de Montpellier, CNRS, INSERM, Montpellier, France
Alain Michel
Laboratoire de Pharmacologie et Physiopathologie Expérimentale, UMR Qualisud, CIRAD–Université de Montpellier, Montpellier, France
Sylvie Rapior
Laboratoire de Botanique, Phytochimie et Mycologie, CEFE, CNRS–Université de Montpellier–Université Paul-Valéry Montpellier–EPHE–IRD, Montpellier, France
Lonsény Traoré
Laboratoire de Technologie Alimentaire du Département de Génie Chimique de l'Université Gamal Abdel Nasser de Conakry, BP 1147, Conakry, Guinée
Patrick Poucheret
Laboratoire de Pharmacologie et Physiopathologie Expérimentale, UMR Qualisud, CIRAD–Université de Montpellier, Montpellier, France
Françoise Fons
Laboratoire de Botanique, Phytochimie et Mycologie, CEFE, CNRS–Université de Montpellier–Université Paul-Valéry Montpellier–EPHE–IRD, Montpellier, France

ABSTRACT

Lentinus edodes (= Lentinula edodes) is an edible mushroom grown and marketed for centuries due to its nutritional and medicinal properties. L. edodes has multiple pharmacological activities as an antioxidant and anti-inflammatory. Few studies were performed taking into account the influence of culture conditions to optimize the biological properties of L. edodes on human health. Our work focused on the comparison of antioxidant capacity and anti-inflammatory activity of L. edodes fruit bodies cultivated by three mushroom producers in the French Occitanie region using the same strain in various growing conditions (organic and nonorganic). Sequential extraction was performed on freeze-dried fungal materials. All extracts have a quantifiable but moderate antioxidant activity measured via DPPH and ORAC tests. The anti-inflammatory activity of the ethanol and aqueous extracts was evaluated on a model of inflammatory macrophages. The ethanol extracts inhibit NO production in a dose-dependent manner when the cells are pretreated for 4 h with a 24 h stimulation time.

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