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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v18.i1.60
pages 49-57

Activity of Extracts from Submerged Cultured Mycelium of Winter Mushroom, Flammulina velutipes (Agaricomycetes), on the Immune System In Vitro

Svetlana Kashina
Division de Ciencias Naturales y Exactas, Departamento de Biologia, Universidad de Guanajuato, Guanajuato, Guanajuato, México
Lerida Liss Flores Villavicencio
Division de Ciencias Naturales y Exactas, Departamento de Biologia, Universidad de Guanajuato, Guanajuato, Guanajuato, México
Silvio Zaina
Division de Ciencias de la Salud, Departamento de Ciencias Médicas, Universidad de Guanajuato, Leon, Guanajuato, México
Marco Balleza Ordaz
Division de Ingenierias, Departamento de Fisica Médica, Universidad de Guanajuato, Leon, Guanajuato, México
Gloria Barbosa Sabanero
Division de Ciencias de la Salud, Departamento de Ciencias Médicas, Universidad de Guanajuato, Leon, Guanajuato, México
Victor Tsutsumi Fujiyoshi
Centro de Investigacion y de Estudios Avanzados, Departamento de Infectomica y Patogénesis Molecular, Unidad Zacatenco, México, México
Myrna Sabanero Lopez
Division de Ciencias Naturales y Exactas, Departamento de Biologia, Universidad de Guanajuato, Guanajuato, Guanajuato, México

ABSTRACT

Extracts from submerged cultured mycelium of two strains of Flammulina velutipes, a popular culinary mushroom, were obtained by ultrasound and tested in vitro to determine their activity in innate immunity (monocytes/ macrophages). In addition, polyclonal antibodies against the extracts were produced. Both extracts have similar glycoproteins that contain mannose and glucose but have different glycoproteins with galactoseamine units. Two novel immunogenic glycoproteins with molecular weights of 32 and 25 kDa have been revealed. It is thought that these proteins are produced only by submerged cultured mycelium. Both extracts show immune-enhancing activity based on the significant modification of various parameters such as cytokine production, phagocytosis, and reactive oxygen species production.


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