图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v18.i1.30
pages 13-21

Development and Validation of an LC-MS/MS Method for the Quantification of Agaritine in Mushrooms

Simon Merdivan
Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt-Universitat, Greifswald, Germany
Christoph Willke
Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt-Universitat, Greifswald, Germany
Ulrike Lindequist
Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

ABSTRACT

Agaritine, an aromatic hydrazine, is found as a secondary metabolite in mushroom species. It is among others suspected to exhibit genotoxic activity. This publication describes the validation of a method for the quantification of agaritine in mushrooms (i.e., extraction and purification by solid phase extraction) and measurement by liquid chromatography with tandem mass spectrometry detection in positive ionization mode. The results show this method to be selective, accurate, and precise. This method could be used for the quality control of pharmaceutical preparations containing mushrooms.


Articles with similar content:

Identification and Quantification of Triterpenoids in Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), with HPLC-MS/MS Methods
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 10
Fan Yang, Zhiyou Wen, Dandan Cai, Huijie Xin, Yanqing Zhang, Yuyu Niu, Leilei Fang, Wuqin Qi, Junbo Xie
Novel Antibacterial Compounds Obtained from Some Edible Mushrooms
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Karuppaiya Periasamy
Therapeutic Effects of Substances Occurring in Higher Basidiomycetes Mushrooms: A Modern Perspective
Critical Reviews™ in Immunology, Vol.19, 1999, issue 1
Solomon P. Wasser, Alexander L. Weis
Methoxyflavones from New Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 8
Satoru Kaifuchi, Yhiya M. Amen, Kuniyoshi Shimizu
Medicinal Mushroom Science: History, Current Status, Future Trends, and Unsolved Problems
International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 1
Solomon P. Wasser