每年出版 12 期
ISSN 打印: 1521-9437
ISSN 在线: 1940-4344
Indexed in
Wild Edible Mushrooms from Turkey as Possible Anticancer Agents on HepG2 Cells Together with Their Antioxidant and Antimicrobial Properties
摘要
This study was designed to reveal cell growth inhibitory potential of six different edible mushrooms: Ramaria flava, Agrocybe molesta, Volvopluteus gloiocephalus, Lactarius deliciosus, Bovista plumbea, and Tricholoma terreum on HepG2 cells together with their antioxidant and antibacterial power. Methanolic extracts of V gloiocephalus and aqueous extracts of R. flava had the most potential cytotoxic effects over HepG2 cells. The best results for 2,2-diphenyl-1-picrylhydrazyl radical scavenging activities were obtained from both aqueous and methanolic extracts of R. flava. Methanolic extracts of T. terreum (IC50 = 1.62 mg/mL) and aqueous extracts of B. plumbea (IC50 = 0.49 mg/mL) showed maximum metal chelating activity. The highest reducing capacities were observed among the methanolic extracts of R. flava (EC50 = 1.65 mg/mL) and aqueous extracts of B. plumbea (EC50 = 1.71 mg/ mL). High-performance liquid chromatography analysis revealed the presence of many phenolic compounds in macrofungi; gallic acid and p-coumaric acid were the two main phenolics identified in all extracts. Antibacterial studies indicated that all six tested mushrooms showed antibacterial activity on at least three microorganisms. These results indicate that different extracts of the investigated mushrooms have considerable cytotoxic, antioxidant, and antibacterial properties and may be utilized as a promising source of therapeutics.
-
Kim Kwan-Chul, Kwon Yong-Beom, Jang Hae-Dong, Kim Jae Wha, Jeong Jae Cheol, Lee Ik-Soo, Ha Byung-Jo, Yoo Ick-Dong, Study on the Antioxidant and Human Neutrophil Elastase Inhibitory Activities of Mushroom Ramaria formosa Extracts, Journal of the Society of Cosmetic Scientists of Korea, 42, 3, 2016. Crossref
-
Li Qiang, Wang Qiangfeng, Jin Xin, Chen Zuqin, Xiong Chuan, Li Ping, Liu Qiaofeng, Huang Wenli, Characterization and comparative analysis of six complete mitochondrial genomes from ectomycorrhizal fungi of the Lactarius genus and phylogenetic analysis of the Agaricomycetes, International Journal of Biological Macromolecules, 121, 2019. Crossref
-
Nowacka-Jechalke Natalia, Olech Marta, Nowak Renata, Mushroom Polyphenols as Chemopreventive Agents, in Polyphenols: Prevention and Treatment of Human Disease, 2018. Crossref
-
Rezaeian Sharareh, Pourianfar Hamid R., A comparative study on cytotoxicity and antiproliferative activities of crude extracts and fractions from Iranian wild-growing and cultivated Agaricus spp., Journal of Food Measurement and Characterization, 12, 4, 2018. Crossref
-
EMSEN Buğrahan, GÜVEN Büşranur, KAYA Abdullah, Yabani Yenilebilir Bir Mantar Olan Lycoperdon molle Pers.'nin Antioksidan ve Antigenotoksik Potansiyeli, Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 22, 5, 2019. Crossref
-
EMSEN BUGRAHAN, OZDEMIR OZLEM, ENGIN TUBANUR, TOGAR BASAK, CAVUSOGLU SEYDA, TURKEZ HASAN, Inhibition of growth of U87MG human glioblastoma cells by Usnea longissima Ach., Anais da Academia Brasileira de Ciências, 91, 3, 2019. Crossref
-
Cheong Peter Chiew Hing, Tan Chon Seng, Fung Shin Yee, Application of Wild Macrofungi as Anticancer Therapeutics, in Biology of Macrofungi, 2018. Crossref
-
Cheng Xiao-Du, Wu Qing-Xi, Zhao Jin, Su Ting, Lu Yong-Ming, Zhang Wen-Na, Wang Ya, Chen Yan, Immunomodulatory effect of a polysaccharide fraction on RAW 264.7 macrophages extracted from the wild Lactarius deliciosus, International Journal of Biological Macromolecules, 128, 2019. Crossref
-
Wu Fang, Zhou Li-Wei, Yang Zhu-Liang, Bau Tolgor, Li Tai-Hui, Dai Yu-Cheng, Resource diversity of Chinese macrofungi: edible, medicinal and poisonous species, Fungal Diversity, 98, 1, 2019. Crossref
-
Koc Behlul, Akyuz Lalehan, Cakmak Yavuz Selim, Sargin Idris, Salaberria Asier M., Labidi Jalel, Ilk Sedef, Cekic Fazilet Ozlem, Akata Ilgaz, Kaya Murat, Production and characterization of chitosan-fungal extract films, Food Bioscience, 35, 2020. Crossref
-
TÜRKEKUL İbrahim, KARAMAN İsa, IŞIK Hakan, Tokat ve Yozgat Bölgelerinden Toplanan Bazı Yenilebilir Mantarların Antimikrobiyal Potansiyeli Üzerine Bir Araştırma, Türk Doğa ve Fen Dergisi, 2020. Crossref
-
Emsen Bugrahan, Sadi Gökhan, Bostanci Aykut, Aslan Ali, In vitro evaluation of cytotoxic, oxidative, genotoxic, and apoptotic activities of physodic acid from Pseudevernia furfuracea in HepG2 and THLE2 cells, Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, 155, 6, 2021. Crossref
-
Stanković Miroslava, Mitić Violeta, Stankov Jovanović Vesna, Dimitrijević Marija, Nikolić Jelena, Stojanović Gordana, Selected fungi of the genus Lactarius - screening of antioxidant capacity, antimicrobial activity, and genotoxicity, Journal of Toxicology and Environmental Health, Part A, 85, 17, 2022. Crossref
-
Kilinc E, Dagistan Y, Kotan B, Cetinkaya A, Effects of Nigella sativa seeds and certain species of fungi extracts on number and activation of dural mast cells in rats, Physiology International, 104, 1, 2017. Crossref
-
Abdelshafy Asem Mahmoud, Belwal Tarun, Liang Ze, Wang Lei, Li Dong, Luo Zisheng, Li Li, A comprehensive review on phenolic compounds from edible mushrooms: Occurrence, biological activity, application and future prospective, Critical Reviews in Food Science and Nutrition, 62, 22, 2022. Crossref