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国际药用蘑菇期刊
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ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v17.i10.90
pages 997-1003

Protective Effect of Ethanol Extracts of the Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes), on the Experimental Middle Cerebral Artery Occlusion/Reperfusion (MCAO/R) Model

Ran Kong
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People's Republic of China
Ying Zhang
Department of Dermatology, The First Hospital of Chinese People's Liberation Army, Gansu, People's Republic of China
Shuofeng Zhang
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People's Republic of China
Min Liu
School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, People's Republic of China
Wenyan Sun
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People's Republic of China
Yue Xing
School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, People's Republic of China
Yalan Guan
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People's Republic of China
Chunchao Han
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China
Zhenquan Liu
School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, People's Republic of China

ABSTRACT

In this study, we investigated the effects of ethanol extracts of Ophiocordyceps sinensis (EEOS) on neuroprotective efficacy in a rat model of focal cerebral ischemia/reperfusion (IR). The effects of EEOS on mortality rate, neurobehavior, grip strength, polymorphonuclear (PMN) cells, interleukin (IL)-1β, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α, intracellular adhesion molecule 1 (ICAM-1), and cyclooxygenase-2 (COX-2) were determined by enzyme-linked immunosorbent assay and immunohistochemistry. The cerebral infarction was examined through tetrazolium chloride staining. EEOS significantly inhibited IR-induced brain production of IL-1β, TNF-α, iNOS, ICAM-1, and COX-2. Moreover, EEOS suppressed infiltration of PMN cells. EEOS caused a significant reduction in the infarct size compared with the middle cerebral artery occlusion group. The study demonstrates the neuroprotective potential of EEOS inhibition of IR through anti-inflammatory activity in a rat model of IR.


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