图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v17.i10.100
pages 1005-1017

Novel Bioactive Wild Medicinal Mushroom−Xylaria sp. R006 (Ascomycetes) against Multidrug Resistant Human Bacterial Pathogens and Human Cancer Cell Lines

Veluchamy Ramesh
Department of Botany, Vivekananda College, Tiruvedagam west, Madurai, Tamilnadu, India
Karnewar Santosh
Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, India
Thangarajan Durai Anand
Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamilnadu, India
Vellasamy Shanmugaiah
Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamilnadu, India
Srigiridhar Kotamraju
Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, India
Chandran Karunakaran
Department of Chemistry, Biomedical Research Lab, VHNSN College, Virudhunagar, Tamilnadu, India
Ayyappan Rajendran
Department of Botany, VHNSN College, Virudhunagar, Tamilnadu, India

ABSTRACT

In the present study, the fruiting body extracts of Xylaria sp. strain R006 were obtained from hexane, ethyl acetate and methanol. Among them, the ethyl acetate extract exhibited significant antimicrobial activities against bacterial and fungal pathogens. Based on the effective antimicrobial activity, the crude ethyl acetate extract was fractionized by two-step siliga gel column chromatography. All the fractions were tested for antibacterial activity against drug resistant Staphylococcus aureus strains (1−10) and Pseudomonas aeruginosa strains (1−8). The fraction E showed a maximum inhibition zone of 27.9 mm against drug resistant S. aureus strain 3 and 29.4 mm against drug resistant P. aeruginosa strain 4. Minimal inhibitory concentration of fraction E showed potential result against all the drug resistant strains however, the lowest concentration of 75 µg/mL−1 was observed against S. aureus strains 1 and 6 and P. aeruginosa strain 3. Further, 60 µg/mL of fraction E had significant cytotoxic activity of 54.9, 55.1 and 54.9% against MDA-MB-231 (breast carcinoma cells), A-549 (lung carcinoma cells) and MCF-7 (breast carcinoma cells) human cancer cell lines, respectively. The spectral data revealed that the fraction E has chromophoric groups in it and had the C = O stretching, C−C = C asymmetric stretch, N-H stretch and C-O stretch as functional groups. The results indicate that the metabolites of fruiting bodies of Xylaria sp. R006 are the potential natural source for the development of new anticancer agents.


Articles with similar content:

Antibacterial Activity of Wild Xylaria sp. Strain R005 (Ascomycetes) Against Multidrug-Resistant Staphylococcus aureus and Pseudomonas aeruginosa
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 1
Annamalai Thalavaipandian, Veluchamy Ramesh, U. S. Ezhil Arivudainambi, Chandran Karunakaran, Ayyappan Rajendran
Characterization of Anti−Salmonella typhi Compounds from Medicinal Mushroom Extracts from Zimbabwe
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 7
Catherine Chidewe, Mudadi A. Benhura, Tsungai Reid, Chenjerayi Kashangura, Takafira Mduluza, Babill Stray-Pedersen
Species of Genus Ganoderma (Agaricomycetes) Fermentation Broth: A Novel Antioxidant and Antimicrobial Agent
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 5
Mirjana Stajić, Jelena Vukojević, Marijana Kosanic, Jasmina Ćilerdžić, Branislav Ranković
Inhibitory Effect of Five Ganoderma Species (Agaricomycetes) against Key Digestive Enzymes Related to Type 2 Diabetes Mellitus
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 7
Hui-Ping Hu, Yi-fan Zhang, Yi-Zhen Xie, Shao-Dan Chen, Tian-Qiao Yong
Antioxidant, Anticancer, Antimicrobial, and Antibiofilm Properties of the Culinary-Medicinal Fairy Ring Mushroom, Marasmius oreades (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 6
Nergiz Demirtas, Naznoosh Shomali, Okan Onar, Ozlem Yildirim, Basar Karaca, Ilgaz Akata, Arzu Coleri Cihan