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ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Novel Bioactive Wild Medicinal Mushroom−Xylaria sp. R006 (Ascomycetes) against Multidrug Resistant Human Bacterial Pathogens and Human Cancer Cell Lines

卷 17, 册 10, 2015, pp. 1005-1017
DOI: 10.1615/IntJMedMushrooms.v17.i10.100
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摘要

In the present study, the fruiting body extracts of Xylaria sp. strain R006 were obtained from hexane, ethyl acetate and methanol. Among them, the ethyl acetate extract exhibited significant antimicrobial activities against bacterial and fungal pathogens. Based on the effective antimicrobial activity, the crude ethyl acetate extract was fractionized by two-step siliga gel column chromatography. All the fractions were tested for antibacterial activity against drug resistant Staphylococcus aureus strains (1−10) and Pseudomonas aeruginosa strains (1−8). The fraction E showed a maximum inhibition zone of 27.9 mm against drug resistant S. aureus strain 3 and 29.4 mm against drug resistant P. aeruginosa strain 4. Minimal inhibitory concentration of fraction E showed potential result against all the drug resistant strains however, the lowest concentration of 75 µg/mL−1 was observed against S. aureus strains 1 and 6 and P. aeruginosa strain 3. Further, 60 µg/mL of fraction E had significant cytotoxic activity of 54.9, 55.1 and 54.9% against MDA-MB-231 (breast carcinoma cells), A-549 (lung carcinoma cells) and MCF-7 (breast carcinoma cells) human cancer cell lines, respectively. The spectral data revealed that the fraction E has chromophoric groups in it and had the C = O stretching, C−C = C asymmetric stretch, N-H stretch and C-O stretch as functional groups. The results indicate that the metabolites of fruiting bodies of Xylaria sp. R006 are the potential natural source for the development of new anticancer agents.

对本文的引用
  1. Rezaeian Sharareh, Pourianfar Hamid R., A comparative study on cytotoxicity and antiproliferative activities of crude extracts and fractions from Iranian wild-growing and cultivated Agaricus spp., Journal of Food Measurement and Characterization, 12, 4, 2018. Crossref

  2. Wong Jack Ho, Ng Tzi Bun, Chan Helen Hei Ling, Liu Qin, Man Gene Chi Wai, Zhang Chris Zhiyi, Guan Suzhen, Ng Charlene Cheuk Wing, Fang Evandro Fei, Wang Hexiang, Liu Fang, Ye Xiuyun, Rolka Krzysztof, Naude Ryno, Zhao Shuang, Sha Ou, Li Chunman, Xia Lixin, Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials, Applied Microbiology and Biotechnology, 104, 11, 2020. Crossref

  3. Nowakowski Patryk, Markiewicz-Żukowska Renata, Bielecka Joanna, Mielcarek Konrad, Grabia Monika, Socha Katarzyna, Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents, Biomedicine & Pharmacotherapy, 143, 2021. Crossref

  4. Park Hye-Jin, Current Uses of Mushrooms in Cancer Treatment and Their Anticancer Mechanisms, International Journal of Molecular Sciences, 23, 18, 2022. Crossref

  5. Keekan K. K., Ranadive K. R., Naik P., Sendker J., Padmaraj S. R., Anti-Methicillin-Resistant S. aureus Activity of Fruiting Body and Mycelial Culture Extracts of Xylaria longipes Nitschke (Ascomycota), Pharmaceutical Chemistry Journal, 56, 7, 2022. Crossref

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