图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.2019030355
pages 381-392

Methyl-Hispolon from Phellinus lonicerinus (Agaricomycetes) Affects Estrogen Signals in MCF-7 Breast Cancer Cells and Premature Aging in Rats

Junzhi Wang
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China; Hubei Engineering Research Center of Biological Ferment, Yichang, Hubei, China
Huifang Lv
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China
Beiyan Chen
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China
Wenfeng Huang
Hubei Key Laboratory of Natural Products Research and Development, Medical College, China Three Gorges University, Yichang, Hubei, China
Ailing Wang
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China
Lanqing Liu
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China
Haibo He
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China; Hubei Engineering Research Center of Biological Ferment, Yichang, Hubei, China
Jianfeng Chen
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China
Shi Li
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China
Wei-Qiao Deng
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, China

ABSTRACT

We studied Phellinus lonicerinus to determine the cytotoxic effect and the dual estrogenic activities of methyl-hispolon and their relation to estrogen signals in vivo and in vitro. The Glide scores of methyl-hispolon-estrogen receptor α (ERα) and methyl-hispolon-ERβ docked complexes were -7.29 kcal/mol and -6.68 kcal/mol in docking simulations. Methyl-hispolon had a significant antiproliferative effect for estrogen-sensitive ER(+) MCF-7 cells in the absence of estrogen, and it exhibited dual estrogen activities. Methyl-hispolon increased the serum E2 in rats with premature ovarian failure and fulfilled the estrogenic function in the uterus and ovary. Methyl-hispolon significantly inhibited the expression of Ras, API, ERα, C-myc, and cyclinDl, as well as their gene transcription in RL95-2 cells. The phosphorylation of ERK1/2 was inhibited by methyl-hispolon. Thus, methyl-hispolon has potential use in treating estrogen deficiency-related diseases, with good antitumor effects and estrogenic activity.

REFERENCES

  1. Velloso FJ, Bianco AF, Farias JO, Torres NE, Ferruzo PY, Anschau V, Jesus-Ferreira HC, Chang TH, Sogayar MC, Zerbini LF, Correa RG., The crossroads of breast cancer progression: insights into the modulation of major signaling pathways. Onco Targets Ther. 2017;10:5491–524.

  2. Tremont A, Lu J, Cole JT. , Endocrine therapy for early breast cancer: updated review. Ochsner J. 2017;17(4):405–11.

  3. Vabre P, Gatimel N, Moreau J, Gayrard V, Picard-Hagen N, Parinaud J, Leandri RD. , Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data. Environ Health. 2017;16(1):37.

  4. Whicker M, Black J, Altwerger G, Menderes G, Feinberg J, Ratner E. , Management of sexuality, intimacy, and menopause symptoms in patients with ovarian cancer. Am J Obstet Gynecol. 2017;217(4):395–403.

  5. Faubion SS, Kuhle CL, Shuster LT, Rocca WA. , Long-term health consequences of premature or early menopause and considerations for management. Climacteric. 2015;18(4):483–91.

  6. Asatiani MD, Wasser SP, Nevo E, Ruimi N, Mahajna J, Reznick AZ., The shaggy ink cap medicinal mushroom, Coprinus comatus (O.F. Mull.: Fr.) Pers. (Agaricomycetideae) substances interfere with H2O2 induction of the NF-kappaB pathway through inhibition of Ika-alpha phosphorylation in MCF7 breast cancer cells. IJMM 2011;13.

  7. Elisashvili V. , Submerged cultivation of medicinal mushrooms: bioprocesses and products (review). Int J Med Mushrooms. 2012;14(3):211–39.

  8. Wang J, Sun W, Luo H, He H, Deng W, Zou K, Liu C, Song J, Huang W. , Protective effect of eburicoic acid of the chicken of the woods mushroom, Laetiporus sulphureus (higher Basidiomycetes), against gastric ulcers in mice. Int J Med Mushrooms. 2015;17(7):619-26.

  9. Morel S, Arnould S, Vitou M, Boudard F, Guzman C, Poucheret P, Fons F, Rapior S., Antiproliferative and antioxidant activities of wild Boletales mushrooms from France. Int J Med Mushrooms. 2018;20(1):13–29.

  10. Lee IK, Yun BS. , Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance. J Antibiot (Tokyo). 2011;64(5):349–59.

  11. Molla MD, Hidalgo-Mora JJ, Soteras MG. , Phytotherapy as alternative to hormone replacement therapy. Front Biosci (Schol Ed). 2011;3:191–204.

  12. Langer RD. , The evidence base for HRT: what can we believe? Climacteric. 2017;20(2):91–6.

  13. Zhao Y, Zheng HX, Xu Y, Lin N. , Research progress in phytoestrogens of traditional Chinese medicine. Zhongguo Zhong Yao Za Zhi. 2017;42(18):3474–87.

  14. Sakamoto T, Horiguchi H, Oguma E, Kayama F. , Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells. J Nutr Biochem. 2010;21(9):856–64.

  15. Jeng YJ, Watson CS. , Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/ F10 cells—the involvement of rapidly activated kinases and caspases. BMC Cancer. 2009;9:334.

  16. Wang J, Hu F, Luo Y, Luo H, Huang N, Cheng F, Deng Z, Deng W, Zou K. , Estrogenic and anti-estrogenic activities of hispolon from Phellinus lonicerinus (Bond.) Bond. et Sing. Fitoterapia. 2014;95:93–101.

  17. Wang J, Chen B, Hu F, Zou X, Yu H, Zhang H, He H, Huang W. , Effect of hispolon from Phellinus lonicerinus (Agaricomycetes) on estrogen receptors, aromatase, and cyclooxygenase II in MCF-7 breast cancer cells. Int J Med Mushrooms. 2017;19(3):233–42.

  18. Yan JK, Pei JJ, Ma HL, Wang ZB, Liu YS. , Advances in antitumor polysaccharides from Phellinus sensu lato: production, isolation, structure, antitumor activity, and mechanisms. Crit Rev Food Sci Nutr. 2017;57(6):1256–69.

  19. Shiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, Agard DA, Greene GL. , The structural basis of estrogen receptor/ coactivator recognition and the antagonism of this interaction by tamoxifen. Cell. 1998;95(7):927–37.

  20. Malamas MS, Manas ES, McDevitt RE, Gunawan I, Xu ZB, Collini MD, Miller CP, Dinh T, Henderson RA, Keith JC Jr, Harris HA. , Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004;47(21):5021–40.

  21. Schrödinger. , Schrödinger software. New York (NY): Schrödinger LLC; 2010. http://www.schrodinger.com. Accessed March 2016.

  22. De Lano WL. , The PyMOL molecular graphics system. San Carlos (CA): DeLano Scientific LLC; 2004. http://pymol. sourceforge.net. Accessed April 2016.

  23. Fu L. , Plant red book of China: Rare threatened plants. Beijing (China): Science Publishing House Press; 1992.

  24. Chen H, Tian T, Miao H, Zhao YY. , Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus: a review. Fitoterapia. 2016;113:6–26.

  25. Huang SM, Chen JY, Chen CC, Su CC, Hu ML. , Black hoof medicinal mushroom Phellinus linteus (Agaricomycetes) extracts protect against radiation-induced hematopoietic abnormality in mice. Int J Med Mushrooms. 2016;18(5):425–31.

  26. Hsieh MJ, Chien SY, Chou YE, Chen CJ, Chen J, Chen MK, Hispolon from Phellinus linteus possesses mediate caspases activation and induces human nasopharyngeal carcinomas cells apoptosis through ERK1/2, JNK1/2 and p38 MAPK pathway. Phytomedicine. 2014;21(12):1746–52.

  27. Chen YS, Lee SM, Lin CC, Liu CY. , Hispolon decreases melanin production and induces apoptosis in melanoma cells through the downregulation of tyrosinase and microphthalmia-associated transcription factor (MITF) expressions and the activation of caspase-3, -8 and -9. Int J Mol Sci. 2014;15.

  28. Lopez-Knowles E, Segal CV, Gao Q, Garcia-Murillas I, Turner NC, Smith I, Martin LA, Dowsett M. , Relationship of PIK3CA mutation and pathway activity with antiproliferative response to aromatase inhibition. Breast Cancer Res. 2014;16(3):R68.

  29. Chowdhury I, Thompson WE, Thomas K. , Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway. J Cell Physiol. 2014;229(8):998–1004.

  30. Shilo A, Ben Hur V, Denichenko P, Stein I, Pikarsky E, Rauch J, Kolch W, Zender L, Karni R. , Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development. RNA. 2014;20(4):505–15.

  31. Castro AF, Campos T, Babcock JT, Armijo ME, Martinez-Conde A, Pincheira R, Quilliam LA., M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells. J Cell Biochem. 2012;113(4):1253–64.

  32. Wang C, Mayer JA, Mazumdar A, Fertuck K, Kim H, Brown M, Brown PH. , Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factor. Mol Endocrinol. 2011;25(9):1527–38.

  33. Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R. , Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. Genes Dev. 1998;12(22):3488–98.


Articles with similar content:

Endoplasmic Reticulum Stress and Angiogenesis in Cancer
International Journal of Physiology and Pathophysiology, Vol.5, 2014, issue 3
Anastasia P. Kharkova, Leonid L. Karbovskyi, Oleksandr H. Minchenko, Dmytro O. Minchenko, Ruslana M. Herasymenko, Roman V. Sulik, Olena V. Hubenia, Kateryna I. Kubaichuk, Iryna V. Kryvdiuk
Antitumoral Activity of Sorafenib in Hepatocellular Carcinoma: Effects on Cell Survival and Death Pathways, Cell Metabolism Reprogramming, and Nitrosative and Oxidative Stress
Critical Reviews™ in Oncogenesis, Vol.21, 2016, issue 5-6
Francisco J. Padillo, Jordi Muntané, Maria A. Rodriguez-Hernandez, Elena Navarro-Villaran, Raul Gonzalez, Francisco J. Molina-Ruiz
Black Tea-Induced Amelioration of Hepatic Oxidative Stress through Antioxidative Activity in EAC-Bearing Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 4
Sreya Chattopadhyay, Tanya Das, Arindam Bhattacharyya, Gaurisankar Sa, Lakshmishri Lahiry, Uttam K. Ghosh, Sankar Bhattacharyya, Deba Prasad Mandal
Targeting the Regulatory Machinery of BIM for Cancer Therapy
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 2
Steven Grant, Hisashi Harada
Protective Effects of Black Hoof Medicinal Mushroom from Korea, Phellinus linteus (Higher Basidiomycetes), on Osteoporosis In Vitro and In Vivo
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 1
Ji Young Shin, Min-Yu Chung, Daeseok Han, In-Ho Kim