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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v19.i3.80
pages 257-265

Preclinical Assessment of Cardiovascular Alterations Induced by Birch Polypore Mushroom, Piptoporus betulinus (Agaricomycetes)

James Oluwagbamigbe Fajemiroye
Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil; Department of Pharmacological Sciences, Federal University of Goias, Campus Samambaia, Goiania, GO, Brazil
Aline A. Mourão
Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goias, Campus Samambaia, Goiania, GO, Brazil
Stefanne Madalena Marques
Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goias, Campus Samambaia, Goiania, GO, Brazil
Lanussy Porfiro de Oliveira
Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil
Jeronimo Raimundo de Oliveira Neto
Department of Pharmacological Sciences, Federal University of Goias, Campus Samambaia, Goiania, GO, Brazil
Abimbola Christanah Elusiyan
Drug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria
Gustavo Rodrigues Pedrino
Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goias, Campus Samambaia, Goiania, GO, Brazil
Elson Alves Costa
Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil
Luiz Carlos da Cunha
Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil
Jordan K. Zjawiony
Division of Pharmacognosy, Department of BioMolecular Sciences, University of Mississippi School of Pharmacy, University, Mississippi

ABSTRACT

Piptoporus betulinus has been used in folk medicine for millennia. However, no data currently exist regarding its potential cardiovascular activity. In this work, the crude ethanolic extract and fractions (hexane, ethyl acetate, and water) with increased polarity from the partitioning process, as well as stigmasterol (the major metabolite isolated from P. betulinus), were administered orally at different doses to normotensive male Wistar rats an hour before recording mean arterial pressure, heart rate, renal blood flow, renal vascular conductance, arterial blood flow, and arterial vascular conductance. The acute oral administration of crude ethanolic extract and all fractions did not alter mean arterial pressure when compared with the control group, which received a vehicle. In addition, subchronic (14 days) oral administration of crude ethanolic extract, fractions, and stigmasterol did not alter cardiovascular parameters. In conclusion, our findings demonstrate that oral administration of organic extracts of P. betulinus did not induce cardiovascular alterations.


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