每年出版 12 期
ISSN 打印: 1521-9437
ISSN 在线: 1940-4344
Indexed in
Effects of Polysaccharides Isolated from Agaricus brasiliensis (Agaricomycetideae) on Splenic Hematopoiesis in Mice
摘要
The administration of ethanol-soluble, boiling water-soluble, and ammonium oxalate-insoluble fractions (essentially β-1, 6-D glucose) isolated from the fruiting bodies of Agaricus brasiliensis into C3H/HeN mice resulted in a marked proliferation of cells of multicell lineages in the splenic compartment. Phenotypically increased expression of NK1.1+ on lymphoid cells and histologically increased proliferations of megakaryocytic progenitor cells were seen in the splenic compartment. These results indicate that β-1, 6-D polysaccharides may play a critical role in the maintenance of hematopoietic cells for compromised patients at the risk of infection associated with malignancy.
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Lemieszek Marta K., Nunes Fernando M., Rzeski Wojciech, Branched mannans from the mushroom Cantharellus cibarius enhance the anticancer activity of natural killer cells against human cancers of lung and colon, Food & Function, 10, 9, 2019. Crossref