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ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

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Isolation and Purification of Polysaccharides with Anti-tumor Activity from Pholiota adiposa (Batsch) P. Kumm. (Higher Basidiomycetes)

卷 14, 册 3, 2012, pp. 271-284
DOI: 10.1615/IntJMedMushr.v14.i3.40
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摘要

Pholiota adiposa is a mushroom with excellent medicinal and nutritional properties. After culture in fermentation medium, Ph. Adiposa mycelia were filtered, lyophilized, and powdered. A crude polysaccharide (PAP) of Ph. Adiposa was prepared from the mycelial powder with hot water, centrifuged, and the resulting supernatant lyophilized. PAP was fractionated by 30%, 60%, and 80% ethanol precipitation steps to yield PAP30, PAP60, and PAP80. Subsequently PAP30-1 and PAP30-2, PAP60-1 and PAP60-2, and PAP80-1 and PAP80-2 were isolated from PAP30, PAP60, and PAP80, respectively, by ion-exchange chromatography on a DEAE-Sepharose column. Polysaccharide content increased from 43.8% in PAP to 50.54%~73.19% in PAP30-1~PAP80-2. The protein content was 4.92% at minimum in these polysaccharide products. In order to identify the chemical composition, the six polysaccharides (PAP30-1, PAP30-2, PAP60-1, PAP60-2, PAP80-1, and PAP80-2) were further purified by gel filtration on Sephacryl S-100-500. Finally, three water-soluble polysaccharides (PAP30-2a, PAP60-2b, and PAP80-2a) were obtained. HPLC analysis revealed that PAP30-2a, PAP60-2b, and PAP80-2a exhibited a molecular weight of 6.6 × 105 Da, 8.4 × 103 Da, and 3.5 × 103 Da, respectively. The glucose content in PAP80-2a, PAP60-2b, and PAP30-2a was 57.8%, 72.7%, and 68.9%, respectively. PAP30-2a, PAP60-2b, and PAP80-2a demonstrated significant differences in anti-tumor activity in mice. PAP80-2a is the optimal bioactive constituent with anti-tumor and T-lymphocyte proliferation stimulating effects.

对本文的引用
  1. Villares Ana, Mateo-Vivaracho Laura, Guillamón Eva, Structural Features and Healthy Properties of Polysaccharides Occurring in Mushrooms, Agriculture, 2, 4, 2012. Crossref

  2. 汪 治云, Progress in the Study of the Biological Activities and Extraction and Purification of Edible Mushroom Polysaccharides, Advances in Microbiology, 04, 03, 2015. Crossref

  3. Friedman Mendel, Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans, Foods, 5, 4, 2016. Crossref

  4. Yuan Xianghe, Zhu Mengjuan, Tian Guoting, Zhao Yongchang, Zhao Liyan, Ng Tzi Bun, Wang Hexiang, Biochemical characteristics of a novel protease from the basidiomyceteAmanita virgineoides, Biotechnology and Applied Biochemistry, 64, 4, 2017. Crossref

  5. Teixeira da Silva Jaime A., Ng Tzi Bun, The medicinal and pharmaceutical importance of Dendrobium species, Applied Microbiology and Biotechnology, 101, 6, 2017. Crossref

  6. Zou Yajie, Du Fang, Hu Qingxiu, Wang Hexiang, The structural characterization of a polysaccharide exhibiting antitumor effect from Pholiota adiposa mycelia, Scientific Reports, 9, 1, 2019. Crossref

  7. Wu Fang, Zhou Li-Wei, Yang Zhu-Liang, Bau Tolgor, Li Tai-Hui, Dai Yu-Cheng, Resource diversity of Chinese macrofungi: edible, medicinal and poisonous species, Fungal Diversity, 98, 1, 2019. Crossref

  8. Lee Jun Won, Park Myung Soo, Park Ji-Hyun, Cho Yoonhee, Kim Changmu, Kim Chang Sun, Jo Jong Won, Lim Young Woon, Taxonomic Study of the Genus Pholiota (Strophariaceae, Basidiomycota) in Korea, Mycobiology, 48, 6, 2020. Crossref

  9. Choudhary Sunil, Characterization and applications of mushroom exopolysaccharides, in New and Future Developments in Microbial Biotechnology and Bioengineering, 2020. Crossref

  10. Rong Chengbo, Song Shuang, Yang Li, Pan Xuejiao, Liu Yu, Wang Shouxian, Breeding of a high-yield strain for commercial cultivation by crossing Pholiota adiposa, Ciência e Agrotecnologia, 45, 2021. Crossref

  11. Kothari Damini, Patel Seema, Kim Soo-Ki, Anticancer and other therapeutic relevance of mushroom polysaccharides: A holistic appraisal, Biomedicine & Pharmacotherapy, 105, 2018. Crossref

  12. Chun Sechul, Gopal Judy, Muthu Manikandan, Antioxidant Activity of Mushroom Extracts/Polysaccharides—Their Antiviral Properties and Plausible AntiCOVID-19 Properties, Antioxidants, 10, 12, 2021. Crossref

  13. Wu Chenlu L, Xu Lili L, Peng Jing, Zhang Danhua H, Al-MPS Obstructs EMT in Breast Cancer by Inhibiting Lipid Metabolism via miR-215-5p/SREBP1, Endocrinology, 163, 5, 2022. Crossref

  14. Yang Zhongwei, Liu Zijing, Xu Jie, Zhu Junmo, Pu Youwei, Bao Yixi, Study on the physicochemical properties and immunomodulatory anti-tumor effect of the Pholiota adiposa polysaccharide, Food & Function, 13, 9, 2022. Crossref

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