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ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Adverse Effects of Mycelia and Culture Broth Extracts from Bjerkandera adusta (Willd.: Fr.) P. Karst. and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. on Breast and Prostate Cancer Cells

卷 9, 册 1, 2007, pp. 39-46
DOI: 10.1615/IntJMedMushr.v9.i1.50
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摘要

Bjerkandera adusta (Willd.: Fr.) P. Karst. (Hapalopilaceae) and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. (Strophariaceae) higher Basidiomycetes are known for their exceptionally high concentrations of adsorbable organic halogens. The objective of this study was to test the effect of these secondary metabolites on breast and prostate cancer cells. We report that ethyl acetate mycelia and culture broth extracts from B. adusta and H. fasciculare inhibit breast cancer MDA-kb2 and MCF-7 cells and prostate cancer PC-3, DU 145, and LNCaP cell viability. Furthermore, H. fasciculare culture broth extract decreases both MDA-kb2, MCF-7, PC-3, DU 145, and LNCaP cell proliferation and transcriptional activity of the androgen receptor in dihydrotestosteron-induced MDA-kb2 cells.

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