每年出版 12 期
ISSN 打印: 1521-9437
ISSN 在线: 1940-4344
Indexed in
Adverse Effects of Mycelia and Culture Broth Extracts from Bjerkandera adusta (Willd.: Fr.) P. Karst. and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. on Breast and Prostate Cancer Cells
摘要
Bjerkandera adusta (Willd.: Fr.) P. Karst. (Hapalopilaceae) and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. (Strophariaceae) higher Basidiomycetes are known for their exceptionally high concentrations of adsorbable organic halogens. The objective of this study was to test the effect of these secondary metabolites on breast and prostate cancer cells. We report that ethyl acetate mycelia and culture broth extracts from B. adusta and H. fasciculare inhibit breast cancer MDA-kb2 and MCF-7 cells and prostate cancer PC-3, DU 145, and LNCaP cell viability. Furthermore, H. fasciculare culture broth extract decreases both MDA-kb2, MCF-7, PC-3, DU 145, and LNCaP cell proliferation and transcriptional activity of the androgen receptor in dihydrotestosteron-induced MDA-kb2 cells.