图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v18.i5.60
pages 425-431

Black Hoof Medicinal Mushroom Phellinus linteus (Agaricomycetes) Extracts Protect Against Radiation-Induced Hematopoietic Abnormality in Mice

Shu-Ming Huang
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, R.O.C.; Department of Nutrition, Nantou Hospital, Ministry of Health and Welfare, Nantou City, Taiwan, R.O.C.
Jen-Yin Chen
Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan, R.O.C.
Chin-Chu Chen
Bioengineering Center, Grape King Bio Ltd, Taoyuan City, Taiwan; Department of Food Science, Nutrition and Nutraceutical Biotechnology, Shih Chien University, Taipei City, Taiwan; Institute of Biotechnology, National Changhua University of Education, Changhua County, Taiwan
Chih-Chung Su
Department of Oncology, Jan-Ai Hospital-DaLi, Taichung, Taiwan, R.O.C.
Miao-Lin Hu
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, R.O.C.; Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan, R.O.C.

ABSTRACT

We investigated the effects of Phellinus linteus extracts (PLEs) against radiation damage in mice. First, BALB/c mice were irradiated once with γ-rays at 4, 5, 6, or 8 Gy and allowed to recover for 20 days. Results reveal that 8-Gy radiation caused death in 100% of mice on day 13, and 6-Gy radiation caused death in 86.7% of mice (13/15) at the end of the experiment, whereas 4- and 5-Gy radiation did not result in any death. We then used 5-Gy γ-ray radiation to examine the protective effects of PLEs. Mice were orally administered a PLE (500, 1000, and 1500 mg/kg) daily for 2 weeks before radiation and for 6 weeks after radiation. γ-Ray radiation significantly decreased body weight starting from week 2 after radiation. Supplementation with a median and high dose of PLE significantly restored body weights starting at weeks 5 and 3, respectively. The radiation-protective agent WR2721 (200 mg/kg intraperitoneally) restored body weights starting at week 4. White blood cells, platelets, red blood cells, and hemoglobin were significantly decreased by radiation, and PLEs (primarily at high doses) and WR2721 significantly prevented hematologic abnormality. These results suggest that PLE has potential as a radioprotective agent.


Articles with similar content:

The Effects of the King Oyster Mushroom Pleurotus eryngii (Higher Basidiomycetes) on Glycemic Control in Alloxan-Induced Diabetic Mice
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 3
Huan Zhan, Ya-li Lei, Jian-Ping Li
Lead Acetate-Induced Hepatoxicity in Wistar Rats: Possible Protective Role of Combination Therapy
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 1
Amita Jaswal, Sadhana Shrivastava, Samta Sharma, Suchita Raghuvanshi, Sangeeta Shukla
Aqueous Extract of Smokeless Tobacco (gutkha) Deregulates Tumor Suppressor and DNA Repair Response in a Murine Model of Smokeless Tobacco Use
Journal of Environmental Pathology, Toxicology and Oncology, Vol.36, 2017, issue 3
Yashmin Choudhury, Mahuya Sengupta, Angom Ranjana Devi
Photochemoprotective Effect of Calluna vulgaris Extract on Skin Exposed to Multiple Doses of Ultraviolet B in SKH-1 Hairless Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 3
Elena Diana Olteanu, Marcela Achim, Pompei Bolfa, Laura Bolojan, Ion Dan Postescu, Adriana Muresan, Doina Daicoviciu, Laurian Vlase, Gabriela Adriana Filip, Simona Clichici
Toxic Effects of Lead Exposure in Rats: Involvement of Oxidative Stress, Genotoxic Effect, and the Beneficial Role of N-Acetylcysteine Supplemented with Selenium
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 1
Samta Sharma, Bhanu Pratap Singh Raghuvanshi, Sangeeta Shukla