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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushr.v12.i4.50
pages 379-389

Pancreas Protective Effect of Button Mushroom Agaricus bisporus (J.E. Lange) Imbach (Agaricomycetidae) Extract on Rats with Streptozotocin-Induced Dia betes

Mustafa Yamac
Eskisehir Osmangazi University, Faculty of Science and Arts, Department of Biology, Eskisehir, Turkey
Gungor Kanbak
Eskisehir Osmangazi University, Medicine Faculty, Department of Biochemistry, Eskisehir, Turkey
Melih Zeytinoglu
Emeritus, Anadolu University, Science Faculty, Department of Biology, Eskisehir, Turkey
Hakan Senturk
Eskisehir Osmangazi University, Science and Arts Faculty, Department of Biology, Eskisehir, Turkey
Gokhan Bayramoglu
Artvin Coruh University, Faculty of Health Sciences, Department of Occupational Health and Safety, Artvin, Turkey
Ali Dokumacioglu
Eskisehir Osmangazi University, Medicine Faculty, Department of Biochemistry, Eskisehir, Turkey
Leonardus Johannes Lambertus Donatus Van Griensven
Plant Research International, Department of Bioscience Wageningen University and Research Centre, POB 16, 6700AA, Wageningen, The Netherlands

ABSTRACT

In the present study we describe the effects of hot water extract of the culinary-medicinal button mushroom, Agaricus bisporus, on the symptoms of streptozotocin-induced diabetes in Sprague Dawley rats. A. bisporus extract at the doses of 0, 100, 200, and 400 mg/kg body weight (bw) per day were orally applied to streptozotocin-induced diabetic rats for a period of 7 days after the onset of the diabetes. Food and water intake and body weight were recorded daily. Upon sacrifice, histological studies were performed on pancreas tissues, and biochemical parameters such as glucose, insulin superoxide dismutase, malondialdehyde and catalase were measured of all experimental groups. The serum glucose levels significantly decreased after oral administration at the dose of 400 mg/kg bw per day by 29.68% with A. bisporus extract. Furthermore, the serum insulin levels in the streptozotocin-induced diabetic rats were increased to 78.50% at the extract dose of 400 mg/kg bw per day. Also, catalase activities and malondialdehyde levels decreased to values slightly above the normal animal control. The most obvious and surprising change was, however, the increase in cellularity of the Langerhans islets of the pancreas and their apparent repopulation with beta cells. We conclude that the oral application of high doses of A. bisporus extract may result in decreased severity of streptozotocin-induced diabetes in rat.


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