图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v18.i11.40
pages 991-998

Evaluation of Antianxiety Potential of Four Ganoderma (Agaricomycetes) Species from India in Mice

Ranjeet Singh
Department of Botany, Punjabi University, Patiala, Punjab, India
Gurpaul Singh Dhingra
Department of Botany, Punjabi University, Patiala, Punjab, India
Richa Shri
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Punjab, India

ABSTRACT

The genus Ganoderma consists of widespread polypore mushrooms that have traditionally been used to reduce stress and anxiety. However, scientific evidence for this is not adequate. Hence, this study was designed to investigate the anxiolytic potential of G. applanatum, G. brownii, G. lucidum, and G. philippii collected from Uttarakhand, India. Various extracts of dried, powdered basidiocarps were prepared using different solvents−namely, petroleum ether, chloroform, methanol, and distilled water−by successive Soxhlet extraction. All the extracts were tested for antianxiety activity using the elevated plus maze (EPM) model in Swiss albino mice. The results showed that the methanol extract of G. lucidum at a dose of 200 mg/kg, administered orally, shows a significant increase in the average time spent in the open arms of the EPM when compared with the control; this was comparable to the effect of the standard drug (diazepam, 2 mg/kg by mouth). This bioactive methanol extract was subjected to bioactivity-guided fractionation. The results show that the n-butanol fraction of the methanol extract evinced significant antianxiety activity at a dose of 100 mg/kg. This fraction showed the presence of phenols and flavonoids and thus was standardized with respect to total phenol content and total flavonoid content. The antianxiety activity may be the result of the phenols/flavonoids present. This study clearly demonstrated that the n-butanol fraction from the methanol extract of G. lucidum can be developed as source of new anxiolytic agents.


Articles with similar content:

Anti-inflammatory Activity of Mycelial Extracts from Medicinal Mushrooms
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 4
Hongyu Xu, Zhenming Lu, Yan Geng, Zheng-Hong Xu, Jin-Song Shi, Shuiling Zhu
Antioxidant, Anti-Inflammatory, and Antitumor Activities of Cultured Mycelia and Fruiting Bodies of the Elm Oyster Mushroom, Hypsizygus ulmarius (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 3
Kainoor K. Janardhanan, Korattuvalappil S. Ravikumar, Karattuthodi Fathimathu Zuhara, Panavalappil Greeshma, Mangalathmelathil N. Neethu, Meera Pandey
Antimicrobial, Cytotoxic, Anti-Inflammatory, and Antioxidant Activity of Culinary Processed Shiitake Medicinal Mushroom (Lentinus edodes, Agaricomycetes) and Its Major Sulfur Sensory-Active Compound−Lenthionine
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 2
Iveta Stefanova, Roman Kubec, Pavel Hrouzek, Jan Hosek, Zuzana Plavcova, Kristyna Kupcova
Activity-Guided Fractionation and Evaluation of Potent Antioxidants from Extract of Angel Wings Mushroom, Pleurotus porrigens (Higher Basidiomycetes)
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 1
Hip Seng Yim, Fook Yee Chye, Chun Wai Ho, Chiaw Mei Sia, Loshnie Samuagam, Sook Yee Mah
In Vitro Anti-Helicobacter pylori Effects of Medicinal Mushroom Extracts, with Special Emphasis on the Lion's Mane Mushroom, Hericium erinaceus (Higher Basidiomycetes)
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 2
Qi Tan, Kangying Yu, Pingzuo Li, Ruina Liu, Xiaodong Shang, Guo-Ping Zhao