图书馆订阅: Guest
国际药用蘑菇期刊

每年出版 12 

ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Implication of ICP0 Translocation and Peroxisome Functions in the Inhibition of HSV-1 by the Antiviral Protein RC28 from the Higher Basidiomycetes Mushroom Rozites caperata

卷 16, 册 6, 2014, pp. 509-517
DOI: 10.1615/IntJMedMushrooms.v16.i6.10
Get accessGet access

摘要

RC28 an antiviral protein of MW 28.25 kD isolated from the edible mushroom Rozites caperata (RC) (=Cortinarius caperatus), was tested for its ability to block HSV-1 functions. The protein blocked the translocation of the immediate early protein ICP0 from the nucleus to the cytoplasm. Target studies using an array of yeast proteins revealed that the protein binds preferentially to some yeast peroxisome proteins. An antagonist of the peroxisome proliferator nuclear receptor complex (PPAR) [2-chloro-5-nitro-(N-pyridyl) benzamide (MW 277.7)] was inhibitory to both HSV-1 and HSV-2 at EC50 values of 5.8 and 10 µM, respectively. Prevention of the cytoplasmic functions of ICP0 and perturbations of peroxisomal metabolism utilized by HSV-1 are likely antiviral targets of the mushroom protein.

Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain